Publications related to Type 1 diabetes

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

The pancreas plays a central role in metabolism. The exocrine pancreas, composed of ductal and acinar cells, secretes and delivers digestive enzymes into the duodenum where they contribute to food digestion. The endocrine pancreas, constituted by the islet ...

EPFL2011

Effects of sonochemical parameters and inorganic ions during the sonochemical degradation of crystal violet in water

César Pulgarin, Fernando Guzman Duque

This work deals with the ultrasonic degradation (800 kHz) of crystal violet (CV) under different experimental conditions. The effects of saturating gas (argon, carbon dioxide and air), CV concentration (2.45-1225 mu mol L-1), pH (3-9) and power (20-80 W) w ...

2011

In Vivo Evidence for Lactate as a Neuronal Energy Source

Pierre Magistretti, Renaud Jolivet

Cerebral energy metabolism is a highly compartmentalized and complex process in which transcellular trafficking of metabolites plays a pivotal role. Over the past decade, a role for lactate in fueling the energetic requirements of neurons has emerged. Furt ...

2011

Calcareous sponge biomineralization: Ultrastructural and compositional heterogeneity of spicules in Leuconia johnstoni Carter, 1871

Anders Meibom, Jaroslaw Hubert Stolarski, Isabelle Domart-Coulon, Christophe Kopp

In contrast to siliceous sponge spicules, the biomineralization in calcareous sponges is poorly understood. In particular, the existence of a differentiated central core in calcareous spicules is still controversial. Here we combine high-spatial resolution ...

2011

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Johan Auwerx, Kristina Schoonjans, Thijs Pols

Incretin-based therapies have shown promise in the treatment of type 2 diabetes. Here we review our current understanding of TGR5 as a target to induce glucagon-like peptide-1 (GLP-1) secretion. These new observations suggest that TGR5 agonists may constit ...

Elsevier Masson2010

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Kamiar Aminian, Stéphane Armand

Gait characteristics and balance are altered in diabetic patients. Little is known about possible treatment strategies. This study evaluates the effect of a specific training programme on gait and balance of diabetic patients. ...

2010

Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy

Douglas Hanahan

The type 1 insulin-like growth factor receptor (IGF-1R) tyrosine kinase is an important mediator of the protumorigenic effects of IGF-I/II, and inhibitors of IGF-1R signaling are currently being tested in clinical cancer trials aiming to assess the utility ...

2010

PPAR gamma Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination

Johan Auwerx

Obesity is associated with a chronic low-grade inflammation that predisposes to insulin resistance and the development of type 2 diabetes. In this metabolic context, gastrointestinal (GI) candidiasis is common. We recently demonstrated that the PPAR gamma ...

Public Library of Science2010

Neurochemical changes in the developing rat hippocampus during prolonged hypoglycemia

Rolf Gruetter, Ramachandra Rao

Hypoglycemia is common during development and is associated with the risk of neurodevelopmental deficits in human infants. The effects of hypoglycemia on the developing hippocampus are poorly understood. The sequential changes in energy substrates, amino a ...

Wiley-Blackwell2010

Type 1 diabetes

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Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

Effects of sonochemical parameters and inorganic ions during the sonochemical degradation of crystal violet in water

In Vivo Evidence for Lactate as a Neuronal Energy Source

Calcareous sponge biomineralization: Ultrastructural and compositional heterogeneity of spicules in Leuconia johnstoni Carter, 1871

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy

PPAR gamma Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination

Neurochemical changes in the developing rat hippocampus during prolonged hypoglycemia

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

In Vivo Evidence for Lactate as a Neuronal Energy Source

Effects of sonochemical parameters and inorganic ions during the sonochemical degradation of crystal violet in water

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Calcareous sponge biomineralization: Ultrastructural and compositional heterogeneity of spicules in Leuconia johnstoni Carter, 1871

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Neurochemical changes in the developing rat hippocampus during prolonged hypoglycemia

PPAR gamma Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination

Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes