Concept
Temperateness (virology)
Related publications (35)
Viral diversity is linked to bacterial community composition in alpine stream biofilms
Tom Ian Battin, Hannes Markus Peter, Paraskevi Pramateftaki, Meriem Bekliz
Biofilms play pivotal roles in fluvial ecosystems, yet virtually nothing is known about viruses in these communities. Leveraging an optimized sample-to-sequence pipeline, we studied the spatiotemporal turnover of dsDNA viruses associated with stream biofil ...
Springer2022A minimalistic cyclic ice-binding peptide from phage display
Harm-Anton Klok, Luciano Andres Abriata, Corey Alfred Stevens, Matthew Gibson, Xudong Kong
Developing molecules that emulate the properties of naturally occurring ice-binding proteins (IBPs) is a daunting challenge. Rather than relying on the (limited) existing structure–property relationships that have been established for IBPs, here we report ...
2021A Vibriophage Takes Antirepression to the Next Level
Melanie Blokesch, Leonardo Filipe Lemos Rocha
Since its isolation by Esther Lederberg, phage lambda and its repressor protein CI have contributed substantially to the advancement of molecular biology. In this issue of Cell Host & Microbe, Silpe et al. (2020) characterize the antirepressor Qtip of Vibr ...
Elsevier2020Generation of a Large Peptide Phage Display Library by Self-Ligation of Whole-Plasmid PCR Product
Christian Heinis, Xudong Kong, Vanessa Carle, Cristina Diaz Perlas, Kaycie Marie Butler
The success of phage display, used for developing target-specific binders based on peptides and proteins, depends on the size and diversity of the library screened, but generating large libraries of phage-encoded polypeptides remains challenging. New pepti ...
2020Development of Tissue Kallikrein Inhibitors for the Treatment of Netherton Syndrome
There is currently no approved treatment for Netherton syndrome, which is a severe, genetic skin disease characterized by chronic inflammation and excessive peeling of the skin. Even though the molecular disease mechanism has been assigned to the unopposed ...
EPFL2019Bypassing bacterial infection in phage display by sequencing DNA released from phage particles
Christian Heinis, Xudong Kong, Camille Villequey
Phage display relies on a bacterial infection step in which the phage particles are replicated to perform multiple affinity selection rounds and to enable the identification of isolated clones by DNA sequencing. While this process is efficient for wild-typ ...
2017New methods for developing (bi)cyclic peptides by phage display
Cyclic peptide ligands are a promising molecular format for the development of therapeutics. They combine some of the advantages of large protein therapeutics (high affinity and specificity) and of small molecule drugs (accessibility to chemical synthesis ...
EPFL2017Phage Selection of Cyclic Peptides for Application in Research and Drug Development
Cyclic peptides can bind to protein targets with high affinities and selectivities, which makes them an attractive modality for the development of research reagents and therapeutics. Additional properties, including low inherent toxicity, efficient chemica ...
2017Peptide-Enhanced Selective Surface Deposition of Polymer-Based Fragrance Delivery Systems
Surface deposition is a critical step in the application of fragrance-containing products. This contribution presents a novel strategy to enhance the deposition of polymer-based fragrance delivery systems onto cotton substrates from the application medium ...
2017Phage selection of chemically stabilized alpha-helical peptide ligands
Christian Heinis, Pierre Vincent Dessen, Philippe Diderich, Davide Bertoldo, Maola Khan Mohammad Golam
Short alpha-helical peptides stabilized by linkages between constituent amino acids offer an attractive format for ligand development. In recent years, a range of excellent ligands based on stabilized alpha-helices were generated by rational design using a ...
2016