Publications related to Syphilis

A new paradigm for leprosy diagnosis based on host gene expression

Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Thyago Leal Calvo

Author summary Despite effective treatment, leprosy is still a significant public health issue in more than 120 countries, with more than 200 000 new cases yearly. The disease is caused mainly by Mycobacterium leprae, a slow-growing bacillus still uncultiv ...

PUBLIC LIBRARY SCIENCE2021

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Francesco Stellacci, Paulo Henrique Jacob Silva, Ahmet Bekdemir, Valeria Cagno, Emma-Rose Janecek, Samuel Thomas Jones, Marie Mueller

Viral infections kill millions yearly. Available antiviral drugs are virus-specific and active against a limited panel of human pathogens. There are broad-spectrum substances that prevent the first step of virus–cell interaction by mimicking heparan sulfat ...

2018

Statistical physics of vaccination

Marcel Salathé, Zhen Wang

Historically, infectious diseases caused considerable damage to human societies, and they continue to do so today. To help reduce their impact, mathematical models of disease transmission have been studied to help understand disease dynamics and inform pre ...

Elsevier Science Bv2016

Identification of Siglec-1 null individuals infected with HIV-1

Jacques Fellay, Amalio Telenti

Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and infection of bystander target cells. To dissect the role of SIGLEC1 in natura, we scan a large population genetic database and identify a loss-of-function variant (Glu88Ter) t ...

Nature Publishing Group2016

In Vivo Activity of the Benzothiazinones PBTZ169 and BTZ043 against Nocardia brasiliensis

Stewart Cole

Background Mycetoma is a neglected, chronic, and deforming infectious disease caused by fungi and actinomycetes. In Mexico, N. brasiliensis is the predominant etiologic agent. Therapeutic alternatives are necessary because the current drug regimens have se ...

Public Library of Science2015

Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis

Stewart Cole, Neeraj Dhar, Claudia Sala, Ruben Hartkoorn, Ming Zhang

Mycobacterium tuberculosis 18b, a streptomycin (STR)-dependent mutant that enters a viable but nonreplicating state in the absence of STR, has been developed as a simple model for drug testing against dormant bacilli. Here, we further evaluated the STR-sta ...

Amer Soc Microbiology2012

Contrasting persistence strategies in Salmonella and Mycobacterium

John McKinney, Anna De Graff Tischler

Long-term survival of persistent bacterial pathogens in mammalian hosts critically depends on their ability to avoid elimination by innate and adaptive immune responses. The persistent human pathogens that cause typhoid fever and tuberculosis exemplify alt ...

2010

Compressed Sensing with Probabilistic Measurements: A Group Testing Solution

Martin Vetterli, Amin Karbasi, Ali Hormati, Mahdi Cheraghchi Bashi Astaneh

Detection of defective members of large populations has been widely studied in the statistics community under the name ``group testing'', a problem which dates back to World War~II when it was suggested for syphilis screening. There the main interest is to ...

2009

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Syphilis

Identifying and Characterizing Trans Women in the Swiss HIV Cohort Study as an Epidemiologically Distinct Risk Group

A new paradigm for leprosy diagnosis based on host gene expression

Quantifying the Effects of Contact Tracing, Testing, and Containment Measures in the Presence of Infection Hotspots

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Statistical physics of vaccination

Identification of Siglec-1 null individuals infected with HIV-1

In Vivo Activity of the Benzothiazinones PBTZ169 and BTZ043 against Nocardia brasiliensis

Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis

Contrasting persistence strategies in Salmonella and Mycobacterium

Compressed Sensing with Probabilistic Measurements: A Group Testing Solution

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A new paradigm for leprosy diagnosis based on host gene expression

Identifying and Characterizing Trans Women in the Swiss HIV Cohort Study as an Epidemiologically Distinct Risk Group

Contrasting persistence strategies in Salmonella and Mycobacterium

Compressed Sensing with Probabilistic Measurements: A Group Testing Solution

Quantifying the Effects of Contact Tracing, Testing, and Containment Measures in the Presence of Infection Hotspots

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Statistical physics of vaccination

Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis

In Vivo Activity of the Benzothiazinones PBTZ169 and BTZ043 against Nocardia brasiliensis

Identification of Siglec-1 null individuals infected with HIV-1