Concept
Axonal transport
Related publications (55)
Information Theory in Transmembrane Transport
The past decades have seen the advent of information theory in various fields, from quantum physics to cosmology.At an intermediary scale between atomic and cosmological scales are biological systems and in particular the cell, as a constitutive element of ...
EPFL2023Axonal and Dendritic Morphology of Excitatory Neurons in Layer 2/3 Mouse Barrel Cortex Imaged Through Whole-Brain Two-Photon Tomography and Registered to a Digital Brain Atlas
Carl Petersen, Sylvain Crochet, Yanqi Liu, Georgios Foustoukos
Communication between cortical areas contributes importantly to sensory perception and cognition. On the millisecond time scale, information is signaled from one brain area to another by action potentials propagating across long-range axonal arborizations. ...
FRONTIERS MEDIA SA2022Transcranial magnetic stimulation of the brain: What is stimulated? - A consensus and critical position paper
Transcranial (electro)magnetic stimulation (TMS) is currently the method of choice to non-invasively induce neural activity in the human brain. A single transcranial stimulus induces a time-varying electric field in the brain that may evoke action potentia ...
ELSEVIER IRELAND LTD2022Cerebral Metabolic Dysfunction at the Acute Phase of Traumatic Brain Injury Correlates with Long-Term Tissue Loss
Adriano Bernini, Ricardo Alberto Corredor Jerez, Neil Graham
Following traumatic brain injury (TBI), cerebral metabolic dysfunction, characterized by an elevated cerebral microdialysis (CMD) lactate/pyruvate (LP) ratio, is associated with poor outcome. However, the exact pathophysiological mechanisms underlying this ...
MARY ANN LIEBERT, INC2022Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism
Henning Paul-Julius Stahlberg, Dongchun Ni
ABCG2 is a multidrug transporter that affects drug pharmacokinetics and contributes to multidrug resistance of cancer cells. In previously reported structures, the reaction cycle was halted by the absence of substrates or ATP, mutation of catalytic residue ...
NATURE RESEARCH2021High resolution CryoEM structure of the ring-shaped virulence factor EspB from Mycobacterium tuberculosis
Stewart Cole, Florence Pojer, Jérémie Piton
The EspB protein of Mycobacterium tuberculosis is a 60 kDa virulence factor, implicated in conjugation and exported by the ESX-1 system of which it may also be a component. Previous attempts to obtain high-resolution maps of EspB by cryo-electron microscop ...
2020Direct observation of water-mediated single-proton transport between hBN surface defects
Aleksandra Radenovic, Evgenii Glushkov, Ahmet Avsar, Jean Camille Benjamin Comtet, Benoît Grosjean
Super-resolution microscopy of defects in a two-dimensional material unveils the transport of single proton charges at solid/water interfaces. Aqueous proton transport at interfaces is ubiquitous and crucial for a number of fields, ranging from cellular tr ...
NATURE PUBLISHING GROUP2020Traction Forces Control Cell-Edge Dynamics and Mediate Distance Sensitivity during Cell Polarization
Franck Claude Raynaud, Alicia Carine Bornert, Zeno Messi
Traction forces are generated by cellular actin-myosin system and transmitted to the environment through adhesions. They are believed to drive cell motion, shape changes, and extracellular matrix remodeling [1 -3] . However, most of the traction force anal ...
2020Altered interplay between endoplasmic reticulum and mitochondria in Charcot-Marie-Tooth type 2A neuropathy
Bernard Schneider, Roman Chrast, Catherine Maclachlan, Nathalie Marie Géraldine Bernard, Cylia Cloé Rochat, Omar El Mansour, Manisha Juneja
Mutations in the MFN2 gene encoding Mitofusin 2 lead to the development of Charcot-Marie-Tooth type 2A (CMT2A), a dominant axonal form of peripheral neuropathy. Mitofusin 2 is localized at both the outer membrane of mitochondria and the endoplasmic reticul ...
NATL ACAD SCIENCES2019A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology
Sameer Mohammad Khaleel Nazeeruddin
Tauopathies are neurodegenerative diseases whose common pathological feature is the intraneuronal accumulation of tau aggregates. Tau protein has various roles in the neuron, among which stabilization of microtubules (MT), regulation of synaptic activity o ...
EPFL2019