Concept
Origin and function of meiosis
Related publications (7)
Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes
Centriole elimination is an essential process that occurs in female meiosis of metazoa to reset centriole number in the zygote at fertilization. How centrioles are eliminated remains poorly understood. Here we visualize the entire elimination process live ...
2016The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice
Johan Auwerx, Kristina Schoonjans
Studies in rodents have shown that male sexual function can be disrupted by fetal or neonatal administration of compounds that alter endocrine homeostasis, such as the synthetic nonsteroidal estrogen diethylstilbestrol (DES). Although the molecular basis f ...
American Society for Clinical Investigation2009The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice
Johan Auwerx, Kristina Schoonjans
The small heterodimer partner (SHP) is an atypical nuclear receptor known mainly for its role in bile acid homeostasis in the enterohepatic tract. We explore here the role of SHP in the testis. SHP is expressed in the interstitial compartment of the adult ...
2007Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans
The mechanisms that ensure coupling between meiotic cell cycle progression and subsequent developmental events, including specification of embryonic axes, are poorly understood. Here, we establish that zyg-11 and the cullin cul-2 promote the metaphase-to-a ...
2004roughex is a dose-dependent regulator of the second meiotic division during Drosophila spermatogenesis
During spermatogenesis, germ cells execute two meiotic divisions, then withdraw from the cell cycle and initiate postmeiotic differentiation. We show that the gene roughex (rux) is a dose-dependent regulator of meiosis II during Drosophila spermatogenesis. ...
1994