Concept
Management of obesity
Related publications (39)
Peer Influence on the Engagement of Fitness Tracker Usage: A Diabetes and Obesity Study
Maintaining a physically active lifestyle is important for diabetic and obese patients, but how to motivate them to exercise and engage them in the long run remains a challenging issue. We aim to motivate their activities using fitness trackers and prevent ...
Ieee2016Long-Term Training with a Brain-Machine Interface-Based Gait Protocol Induces Partial Neurological Recovery in Paraplegic Patients
Hannes Bleuler, Solaiman Shokur, Simon Gallo, Miguel Nicolelis
Brain-machine interfaces (BMIs) provide a new assistive strategy aimed at restoring mobility in severely paralyzed patients. Yet, no study in animals or in human subjects has indicated that long-term BMI training could induce any type of clinical recovery. ...
Nature Publishing Group2016Persistent spatial clusters of high body mass index in a Swiss urban population as revealed by the 5-year GeoCoLaus longitudinal study
Stéphane Joost, Idris Guessous, Murielle Bochud, Joël Chételat, Fred Michel Paccaud
OBJECTIVE Body mass index (BMI) may cluster in space among adults and be spatially dependent. Whether and how BMI clusters evolve over time in a population is currently unknown. We aimed to determine the spatial dependence of BMI and its 5-year evolution i ...
Bmj Publishing Group2016Protein acetylation in metabolism - metabolites and cofactors
Johan Auwerx, Elena Katsyuba, Hongbo Zhang, Keir Joe Menzies
Reversible acetylation was initially described as an epigenetic mechanism regulating DNA accessibility. Since then, this process has emerged as a controller of histone and nonhistone acetylation that integrates key physiological processes such as metabolis ...
Nature Publishing Group2016Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying
Henry Markram, Julie Meystre, Maurizio Ferdinando Pezzoli, Johannes Le Coutre, Susana Camacho Romero
Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown. Cinnamaldehyde (CIN) imparts the characteristic flavor to cinnamon and is known to be the main agonist of transient receptor potential-ankyrin r ...
Nature Publishing Group2015Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
Kristina Schoonjans, Alessia Perino
The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic steatosis and biliary cholestasis. In contrast to systemic therapy, bile a ...
Nature Publishing Group2015Protein acetylation in metabolism-metabolites and cofactors
Johan Auwerx, Elena Katsyuba, Hongbo Zhang, Keir Joe Menzies
Reversible acetylation was initially described as an epigenetic mechanism regulating DNA accessibility. Since then, this process has emerged as a controller of histone and nonhistone acetylation that integrates key physiological processes such as metabolis ...
2015Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle
Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Laurent Mouchiroud, Evan Graehl Williams, Norman Lionel Moullan, Hongbo Zhang, Eija Riitta Pirinen, Keir Joe Menzies, Laia Morato Fornaguera, Wei Li
We previously demonstrated that the deletion of the poly(ADP-ribose) polymerase (Parp)-1 gene in mice enhances oxidative metabolism, thereby protecting against diet-induced obesity. However, the therapeutic use of PARP inhibitors to enhance mitochondrial f ...
Elsevier2014Vitamin D and energy homeostasis-of mice and men
Johan Auwerx, Kristina Schoonjans, Alessia Perino
The vitamin D endocrine system has many extraskeletal targets, including adipose tissue. 1,25-Dihydroxyvitamin D-3, the active form of vitamin D, not only increases adipogenesis and the expression of typical adipocyte genes but also decreases the expressio ...
Nature Publishing Group2014Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers
Johan Auwerx, Evan Graehl Williams
Nonalcoholic fatty liver disease (NAFLD) affects up to 30% of the adult population in Western societies, yet the underlying molecular pathways remain poorly understood. Here, we identify the dimeric Activator Protein 1 as a regulator of NAFLD. Fos-related ...
Elsevier2014