Concept

Alpha helix

Related publications (200)

1,1-Bi(trishomobarrelenyl) - Synthesis and Chiroptic Properties

1,1-Bi(endo,exo,syn-pentacyclo[3.3.3.02,4.06,8.09,11]undecyl)[1,1-bi(trishomobarrelenyl)] (4) has been prepared as a 1:1 mixture of its meso- and d,l-diastereomers in six steps from trishomobarrelene 1 via the amine 5, the N,N-bis(trishomobarrelenyl)sulfam ...

2009

Nonfouling Polypeptide Brushes via Surface-initiated Polymerization of N-epsilon-oligo(ethylene glycol)succinate-L-lysine N-carboxyanhydride

Jian Wang, Harm-Anton Klok, Matthew Gibson, Raphaël Barbey

This contribution describes the preparation of nonfouling polypeptide brushes via surface-initiated ring-opening polymerization of oligo(ethylene glycol) modified L-lysine N-carboxyanhydrides. Circular dichroism experiments indicated that these surface-anc ...

2009

Effects of N-terminus substitution on the structure and spectroscopy of gas-phase helices

Thomas Rizzo

Because of the importance of helices in the secondary structure of proteins, we have undertaken a study of their spectroscopy, fragmentation patterns and conformations in the gas phase. In this work, we describe the effects of substitution at the N-terminu ...

2008

Amyloid ß-derived switch-peptides as tool to study conformational changes relevant in degenerative diseases

Marie-Stéphanie Camus

The rapid growing number of patients diagnosed with a neurodegenerative disease and more particularly with Alzheimer's disease (AD) has stimulated intensive research in determining and understanding biological phenomena causing such devastating diseases an ...

EPFL2008

Self-assembly of polypeptide/pi-conjugated polymer/polypeptide triblock copolymers in rod-rod-rod and coll-rod-coil conformations

Mohamad Hojeij, Raffaele Mezzenga

Self-assembly in the bulk of a series of hybrid triblock copolymers formed by a poly(9,9-dihexylfluorene-2,7-diyl) (PHF) middle block and two poly(gamma-benzyl-L-glutamate) (PBLG) end blocks has been studied. Since the alpha-helical secondary structure of ...

American Chemical Society2008

Solute energy based REMD

Molecular dynamics (MD) simulations have increasingly contributed to the understanding of biomolecular processes, allowing for predictions of thermodynamic and structural properties. Unfortunately, the holy grail of protein structure prediction was soon fo ...

EPFL2008

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

Pentameric ligand-gated ion channels from the Cys-loop family mediate fast chemo-electrical transduction, but the mechanisms of ion permeation and gating of these membrane proteins remain elusive. Here we present the X-ray structure at 2.9 A resolution of ...

Nature Publishing Group2008

Solution behavior of peptide and peptide-hybrid materials

Harald Nuhn

Peptide based and peptide hybrid materials represent two interesting and challenging classes of biomaterials. Both classes consist of and contain, respectively, one or more polypeptide blocks, endowing the resulting polymers with enhanced self-assembly pro ...

EPFL2008

Topologically based multipolar reconstruction of electrostatic interactions in multiscale simulations of proteins

Matteo Dal Peraro, Michele Cascella, Paolo Carloni

We present a new method to incorporate electrostatic interactions in coarse-grained representations of proteins. The model is based on a topologically reconstructed multipolar expansion of the all-atom centers of charge, specifically of the backbone dipole ...

2008

Toward the design of highly efficient, readily accessible peptide N-caps for the induction of helical conformations

Richard Alan Mimna

A series of novel peptide N-caps was designed with an emphasis on ease of synthesis and an abundance of hydrogen bond acceptors. Different scaffolds based on sugars, cyclic hydrocarbons, and amino acids are developed with a variety of hydrogen bond accepto ...

Kluwer Academic Publishers, Springer2007

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