Concept

Crystallin

Related publications (9)

The Appearance of the Warburg Effect in the Developing Avian Eye Characterized In Ovo: How Neurogenesis Can Remodel Neuroenergetics

Rolf Gruetter, Carole Poitry-Yamate, Antoine Timothée Cherix, Laurent Brodier

PURPOSE. The avian eye is an established model for exploring mechanisms that coordinate morphogenesis and metabolism during embryonic development. Less is known, however, about trafficking of bioenergetic and metabolic signaling molecules that are involved ...

2020

Silicone as a Multifunctional Material: Ultrafast Tuneable Lenses and Energy Harvesting Based on Silicone Membranes

Herbert Shea, Samuel Rosset, Luc Maffli, Michele Ghilardi

In recent years, the development of soft and stretchable electronics and sensors has seen the wide use of Polydimethylsiloxane (PDMS) as a convenient soft substrate on which such circuits are fabricated. When coupled with compliant electrodes, silicone mem ...

2014

Analysis of the Cytoprotective Role of alpha-Crystallins in Cell Survival and Implication of the alpha A-Crystallin C-Terminal Extension Domain in Preventing Bax-Induced Apoptosis

Séverine Hamann

alpha-Crystallins, initially described as the major structural proteins of the lens, belong to the small heat shock protein family. Apart from their function as chaperones, alpha-crystallins are involved in the regulation of intracellular apoptotic signals ...

Public Library of Science2013

Phase separation in binary eye lens protein mixtures

Nicolas Dorsaz, Giuseppe Foffi

Liquid–liquid phase separation occurs in young mammalian eye lenses and in concentrated solutions of isolated eye lens proteins, and has been linked to some forms of cataract. Here we study theoretically the protein compositions and cloud temperatures of t ...

2011

Colloidal characterization and thermodynamic stability of binary eye lens protein mixtures

Nicolas Dorsaz, Giuseppe Foffi

We present a study of binary mixtures of eye lens crystallin proteins. A coarse-grained model of aqueous aand γ-crystallin mixtures based on molecular dynamics simulations and SANS experiments is proposed. Thermodynamic perturbation theory is implemented t ...

2009

A colloidal approach to eye lens protein mixtures

Nicolas Dorsaz

A broad and constantly growing class of diseases, such as Alzheimer's disease, sickle-cell or cataract, involves protein association phenomena as an essential aspect. The common denominator of all the members of this class of molecular condensation disease ...

EPFL2009

Spinodal surface of a free energy model for eye lens protein mixtures: Relevance for cataracts

Nicolas Dorsaz, Giuseppe Foffi

We studied the phase behavior of a model binary mixture of eye lens crystallin proteins using first-order thermodynamic perturbation theory. The instability boundary, or spinodal surface, was found to be very sensitive to the strength of the attraction bet ...

Amer Inst Physics, 2 Huntington Quadrangle, Ste 1No1 D, Melville, Ny 11747-4501 Usa2009

A fibreoptic light distributor for the preventative photodynamic therapy of secondary cataract

Hubert van den Bergh, Boris Clément Karamata

A device for the preventative photodynamic therapy of secondary cataract has been developed. Disturbance of the epithelial cells of the crystalline lens during the primary cataract surgery and/or their migration thereafter can frequently generate secondary ...

2000

Process development for the production of a-cyclodextrin

Albert Renken

A process was developed to utilize the highly active cyclodextrin glycosyltransferase [9030-09-5] from Klebsiella pneumoniae M5 al for a-cyclodextrin (I) [10016-20-3] prodn. To maximize the I yield, decanol was used to ppt. I during the reaction. Thus, yie ...

1982

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