Concept
Glyoxylate cycle
Related publications (59)
Metabolic dependencies of metastasis-initiating cells in breast cancer
Metastasis is the process by which cancer cells from the primary tumor travel through the blood stream to generate a secondary tumor site in a distant organ. Although very few cells are able to make this journey, the resulting effects are dire since most c ...
EPFL2023Identification of New Vulnerabilities in Conjunctival Melanoma Using Image-Based High Content Drug Screening
Gerardo Turcatti, Fabien Kuttler, Mathieu Quinodoz, Olivier Michielin
Recent evidence suggests that numerous similarities exist between the genomic landscapes of both conjunctival and cutaneous melanoma. Since alterations of several components of the MAP kinases, PI3K/mTOR, and cell cycle pathways have been reported in conju ...
2022Detection of myocardial medium‐chain fatty acid oxidation and tricarboxylic acid cycle activity with hyperpolarized [1– 13 C]octanoate
Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara
Under normal conditions, the heart mainly relies on fatty acid oxidation to meet its energy needs. Changes in myocardial fuel preference are noted in the diseased and failing heart. The magnetic resonance signal enhancement provided by spin hyperpolarizati ...
2020Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells
Loïc Dayon, Andreas Wiederkehr, Sofia Moco, Isabelle Chareyron
Aims/hypothesis In islets from individuals with type 2 diabetes and in islets exposed to chronic elevated glucose, mitochondrial energy metabolism is impaired. Here, we studied early metabolic changes and mitochondrial adaptations in human beta cells durin ...
2020