January 4 – Jean Baptiste Gay, vicomte de Martignac succeeds the Comte de Villèle, as Prime Minister of France.
January 8 – The Democratic Party of the United States is organized.
January 22 – Arthur Wellesley, 1st Duke of Wellington succeeds Lord Goderich as Prime Minister of the United Kingdom.
February 19 – The Boston Society for Medical Improvement is established in the United States.
February 21 – The first American-Indian newspaper in the United States is published, named "Cherokee Phoenix".
February 22 – Treaty of Turkmenchay: By this Russian-Persian peace treaty signed on February 10 at Torkamanchay, Persia (Iran), the latter country is forced irrevocably to cede the territories of the Erivan Khanate (most of present-day central Armenia and the northern Iğdır Province of Turkey), the Nakhichevan Khanate (most of the modern-day Nakhchivan Autonomous Republic of Azerbaijan), the remainder of the Talysh Khanate (southeastern Azerbaijan), and the Ordubad and Mughan regions (also part of modern-day Azerbaijan) to Imperial Russia. By this and the Treaty of Gulistan (1813) it has now lost all its territories north of the Aras River, comprising modern-day Georgia, Dagestan, Azerbaijan and Armenia to Russia. Armenians from Persian Azerbaijan are to be resettled in the Caucasus.
March 3 – Dom Pedro I, Emperor of Brazil and former King of Portugal, signs a document "to complete my abdication of the Portuguese crown" (made in 1826), to renounce all claims in favor of his daughter Queen Maria II, and to declare "indubitable proof" that he wishes Portugal to be "perpetually separated from the Brazilian nation....in such a manner as may render even the idea of reunion impracticable."
March 18 – Simón Bolívar, President of Colombia (and former President of Venezuela, Peru and Bolivia), departs from the capital at Bogotá, in order to help his ally, General José Antonio Páez, suppress an uprising near the Venezuelan border, but is sidetracked by another rebellion in Cartagena.
April 11 – Bahía Blanca (present-day Argentina) is founded.