December 11220 – Emperor Xian of Han is forced to abdicate the throne by Cao Cao's son Cao Pi, ending the Han dynasty. 361 – Julian enters Constantinople as sole Roman Emperor. 861 – Assassination of the Abbasid caliph al-Mutawakkil by the Turkish guard, who raise al-Muntasir to the throne, start of the "Anarchy at Samarra". 969 – Byzantine Emperor Nikephoros II Phokas is assassinated by his wife Theophano and her lover, the later Emperor John I Tzimiskes. 1041 – Michael V, adoptive son of Empress Zoë of Byzantium, is proclaimed emperor of the Eastern Roman Empire.
April 5823 – Lothair I is crowned King of Italy by Pope Paschal I. 919 – The second Fatimid invasion of Egypt begins, when the Fatimid heir-apparent, al-Qa'im bi-Amr Allah, sets out from Raqqada at the head of his army. 1242 – During the Battle on the Ice of Lake Peipus, Russian forces, led by Alexander Nevsky, rebuff an invasion attempt by the Teutonic Knights. 1536 – Charles V makes a Royal Entry into Rome, demolishing a swath of the city to re-enact a Roman triumph.
March 31307 – After divorcing his wife Minervina, Constantine marries Fausta, daughter of the retired Roman emperor Maximian. 1146 – Bernard of Clairvaux preaches his famous sermon in a field at Vézelay, urging the necessity of a Second Crusade. Louis VII is present, and joins the Crusade. 1492 – Queen Isabella of Castile issues the Alhambra Decree, ordering her 150,000 Jewish and Muslim subjects to convert to Christianity or face expulsion. 1521 – Ferdinand Magellan and fifty of his men came ashore to present-day Limasawa to participate in the first Catholic mass in the Philippines.
April 261336 – Francesco Petrarca (Petrarch) ascends Mont Ventoux. 1478 – The Pazzi family attack on Lorenzo de' Medici in order to displace the ruiling Medici family kills his brother Giuliano during High Mass in Florence Cathedral. 1564 – Playwright William Shakespeare is baptized in Stratford-upon-Avon, Warwickshire, England (date of birth is unknown). 1607 – The Virginia Company colonists make landfall at Cape Henry. 1721 – A massive earthquake devastates the Iranian city of Tabriz.
May 12254 – Pope Stephen I succeeds Pope Lucius I, becoming the 23rd pope of the Catholic Church, and immediately takes a stand against Novatianism. 907 – Zhu Wen forces Emperor Ai into abdicating, ending the Tang dynasty after nearly three hundred years of rule. 1191 – Richard I of England marries Berengaria of Navarre in Cyprus; she is crowned Queen consort of England the same day. 1328 – Antipope Nicholas V, a claimant to the papacy, is consecrated in Rome by the Bishop of Venice.
October 29312 – Constantine the Great enters Rome after his victory at the Battle of the Milvian Bridge, stages a grand adventus in the city, and is met with popular jubilation. Maxentius' body is fished out of the Tiber and beheaded. 437 – Valentinian III, Western Roman Emperor, marries Licinia Eudoxia, daughter of his cousin Theodosius II, Eastern Roman Emperor in Constantinople unifying the two branches of the House of Theodosius. 1268 – Conradin is executed along with his companion Frederick I, Margrave of Baden by Charles I of Sicily.
September 2848 BC – Pompey disembarks at Pelusium upon arriving in Egypt, whereupon he is assassinated by order of King Ptolemy XIII. 235 – Pope Pontian resigns. He is exiled to the mines of Sardinia, along with Hippolytus of Rome. 351 – Constantius II defeats the usurper Magnentius. 365 – Roman usurper Procopius bribes two legions passing by Constantinople, and proclaims himself emperor. 935 – Duke Wenceslaus I of Bohemia is murdered by a group of nobles led by his brother Boleslaus I, who succeeds him.
August 22392 – Arbogast has Eugenius elected Western Roman Emperor. 851 – Battle of Jengland: Erispoe defeats Charles the Bald near the Breton town of Jengland. 1138 – Battle of the Standard between Scotland and England. 1485 – The Battle of Bosworth Field occurs; Richard III dies, marking the end of the House of Plantagenet. 1559 – Spanish archbishop Bartolomé Carranza is arrested for heresy. 1614 – Fettmilch Uprising: Jews are expelled from Frankfurt, Holy Roman Empire, following the plundering of the Judengasse.
July 16622 – The Hijrah of Muhammad begins, marking the beginning of the Islamic calendar. 997 – Battle of Spercheios: Bulgarian forces of Tsar Samuel are defeated by a Byzantine army under general Nikephoros Ouranos at the Spercheios River in Greece. 1054 – Three Roman legates break relations between Western and Eastern Christian Churches through the act of placing a Papal bull (of doubtful validity) of Excommunication on the altar of Hagia Sophia during Saturday afternoon divine liturgy.
March 22106 – Start of the Bostran era, the calendar of the province of Arabia Petraea. 235 – Roman emperor Severus Alexander is murdered, marking the start of the Crisis of the Third Century. 871 – Æthelred of Wessex is defeated by a Danish invasion army at the Battle of Marton. 1185 – Battle of Yashima: the Japanese forces of the Taira clan are defeated by the Minamoto clan. 1312 – Vox in excelso: Pope Clement V dissolves the Order of the Knights Templar. 1508 – Ferdinand II of Aragon commissions Amerigo Vespucci chief navigator of the Spanish Empire.