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The human back, also called the dorsum (: dorsa), is the large posterior area of the human body, rising from the top of the buttocks to the back of the neck. It is the surface of the body opposite from the chest and the abdomen. The vertebral column runs the length of the back and creates a central area of recession. The breadth of the back is created by the shoulders at the top and the pelvis at the bottom. Back pain is a common medical condition, generally benign in origin. Structure The central feature of the human back is the vertebral column, specifically the length from the top of the thoracic vertebrae to the bottom of the lumbar vertebrae, which houses the spinal cord in its spinal canal, and which generally has some curvature that gives shape to the back. The ribcage extends from the spine at the top of the back (with the top of the ribcage corresponding to the T1 vertebra), more than halfway down the length of the back, leaving an area with less protection between

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FIRST RESULTS OF SPACE CHARGE SIMULATIONS FOR THE NOVEL MULTI-TURN INJECTION

Matthieu George

Recently, a novelmulti-turn injection technique was proposed. It is based on beam merging via resonance crossing. The various beamlets are successively injected and merged back by crossing a stable resonance generated by non-linear magnetic fields. Space charge is usually a crucial effect at injection in a circular machine and it could have an adverse impact on the phase space topology required for merging the various beamlets. Numerical simulations were performed to assess the stability of the merging process as a function of injected beam charge. The results are presented and discussed in this paper.

2010

Assistance using adaptive oscillators: Robustness to errors in the identification of the limb parameters

Alessandro Crespi, Auke Ijspeert, Mike Domenik Rinderknecht, Renaud Ronsse

This paper provides a robustness analysis of the method we recently developed for rhythmic movement assistance using adaptive oscillators. An adaptive oscillator is a mathematical tool capable of extracting high-level features (i.e. amplitude, frequency, offset) of a quasi-sinusoidal measured movement, a rhythmic flexion-extension of the elbow in this case. By the use of a simple inverse dynamical model, the system can predict the torque produced by a human participant, such that a fraction of this estimated torque is fed back through a series elastic actuator to provide movement assistance. This paper objectives are twofold. First, we introduce a new 1 DOF assistive device developed in our lab. Second, we derive model-based predictions and conduct experimental validations to measure the variations in movement frequency as a function of the open parameters of the inverse dynamical model. As such, the paper provides an estimation of the robustness of our method due to model approximations. As main result, the paper reveals that the movement frequency is particularly robust to errors in the estimation of the damping coefficient. This is of high interest for the applicability of our approach, this parameter being in general the most difficult to identify.

IEEE2011

Spatiotemporal Imaging of Water in Operating Voltage-Gated Ion Channels Reveals the Slow Motion of Interfacial Ions

Maksim Eremchev, Aleksandra Radenovic, Sylvie Roke, Orly Bagunu Tarun

Ion channels are responsible for numerous physiological functions ranging from transport to chemical and electrical signaling. Although static ion channel structure has been studied following a structural biology approach, spatiotemporal investigation of the dynamic molecular mechanisms of operational ion channels has not been achieved experimentally. In particular, the role of water remains elusive. Here, we perform label-free spatiotemporal second harmonic (SH) imaging and capacitance measurements of operational voltage-gated alamethicin ion channels in freestanding lipid membranes surrounded by aqueous solution on either side. We observe changes in SH intensity upon channel activation that are traced back to changes in the orientational distribution of water molecules that reorient along the field lines of transported ions. Of the transported ions, a fraction of 10–4 arrives at the hydrated membrane interface, leading to interfacial electrostatic changes on the time scale of a second. The time scale of these interfacial changes is influenced by the density of ion channels and is subject to a crowding mechanism. Ion transport along cell membranes is often associated with the propagation of electrical signals in neurons. As our study shows that this process is taking place over seconds, a more complex mechanism is likely responsible for the propagation of neuronal electrical signals than just the millisecond movement of ions.

2019

BIOENG-448: Fundamentals of neuroengineering

Neuroengineering is at the frontier between neuroscience and engineering: understanding how the brain works allows developing engineering applications and therapies of high impact, while the design of new measurement and data analysis techniques contributes to advance our knowledge about the brain.

Low back pain

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