Publications related to Sonic hedgehog protein

Multi-species atlas resolves an axolotl limb development and regeneration paradox

Can Aztekin, Jixing Zhong, Georgios Tsissios, Evangelia Skoufa

Humans and other tetrapods are considered to require apical-ectodermal-ridge (AER) cells for limb development, and AER-like cells are suggested to be re-formed to initiate limb regeneration. Paradoxically, the presence of AER in the axolotl, a primary mode ...

Berlin2023

Reaction wavefront theory of notochord segment patterning

Andrew Charles Oates

The vertebrate axis is segmented into repetitive structures, the vertebrae. In fish, these segmented structures are thought to form from the paraxial mesoderm and the adjacent notochord. Recent work revealed an autonomous patterning mechanism in the zebraf ...

FRONTIERS MEDIA SA2022

Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation

Gioele La Manno, Alex Russell Lederer, Irina Khven

Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) are a promising cell source to treat age-related macular degeneration (AMD). Despite several ongoing clinical studies, a detailed mapping of transient cellular states during in v ...

CELL PRESS2022

Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non- and anti-adipogenic in age-dependent manner

Bart Deplancke, Julie Marie Russeil, Horia Hashimi, Daniel Alpern, Maria Litovchenko, Pernille Yde Rainer, Magda Zachara, Radiana Ferrero

Adipose stem and precursor cells (ASPCs) give rise to adipocytes and determine the composition and plasticity of adipose tissue. Recently, several studies have demonstrated that ASPCs partition into at least three distinct cell subpopulations, including th ...

WILEY2022

Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster

Denis Duboule, Lucille Delisle, Jozsef Zakany, Leonardo Beccari

In this study, Amandio et al. sought to understand the functions of the highly conserved CTCF sites distributed over the Hox gene clusters. The authors produced an allelic series of cumulative in cis mutations in these sites, up to the abrogation of CTCF b ...

COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2021

Fryns type mesomelic dysplasia of the upper limbs caused by inverted duplications of the HOXD gene cluster

Denis Duboule

The HoxD cluster is critical for vertebrate limb development. Enhancers located in both the telomeric and centromeric gene deserts flanking the cluster regulate the transcription of HoxD genes. In rare patients, duplications, balanced translocations or inv ...

NATURE PUBLISHING GROUP2020

Patterning and mechanics of somite boundaries in zebrafish embryos

Andrew Charles Oates, Sundar Ram Naganathan

The body axis of vertebrates is subdivided into repetitive compartments called somites, which give rise primarily to the segmented architecture of the musculoskeletal system in the adult body. Somites form in a sequential and rhythmic manner in embryos and ...

2020

Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells

Matthias Lütolf, Felix Naef, Yoji Tabata, Eric Paquet, François Réal Rivest, Ambroise Roger Vuaridel, Andrea Manfrin

Signaling centers, localized groups of cells that secrete morphogens, play a key role in early development and organogenesis by orchestrating spatial cell fate patterning. Here we present a microfluidic approach that exposes human pluripotent stem cell (hP ...

NATURE PUBLISHING GROUP2019

Consensus guidelines for the use and interpretation of angiogenesis assays

Michele De Palma, George Coukos, Patrycja Nowak-Sliwinska, Elizabeth Anne Allen, Yan Gong

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that ...

2018

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Sonic hedgehog protein

Multi-species atlas resolves an axolotl limb development and regeneration paradox

Reaction wavefront theory of notochord segment patterning

Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation

Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non- and anti-adipogenic in age-dependent manner

Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster

Fryns type mesomelic dysplasia of the upper limbs caused by inverted duplications of the HOXD gene cluster

Patterning and mechanics of somite boundaries in zebrafish embryos

Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification

Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells

Consensus guidelines for the use and interpretation of angiogenesis assays

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Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification

Multi-species atlas resolves an axolotl limb development and regeneration paradox

Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation

Consensus guidelines for the use and interpretation of angiogenesis assays

Reaction wavefront theory of notochord segment patterning

Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non- and anti-adipogenic in age-dependent manner

Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster

Fryns type mesomelic dysplasia of the upper limbs caused by inverted duplications of the HOXD gene cluster

Patterning and mechanics of somite boundaries in zebrafish embryos

Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells