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Irina Khven

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Related publications (7)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

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Prof. La Manno Group

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Statistical inference with a manifold-constrained RNA velocity model uncovers cell cycle speed modulations

Felix Naef, Gioele La Manno, Alex Russell Lederer, Irina Khven, Antonio Herrera Camacho, Albert Dominguez Mantes, Colas Noé Droin, Lorenzo Talamanca

Across biological systems, cells undergo coordinated changes in gene expression, resulting in transcriptome dynamics that unfold within a low-dimensional manifold. While low-dimensional dynamics can be extracted using RNA velocity, these algorithms can be ...

2024

Fine-grained mapping of neural progenitors subtypes in the embryonic brain unveils context-dependent roles of signalling on cell fate decisions

The mammalian brain develops through precisely orchestrated events that transform a simple neural tube into a complex structure. While single-cell RNA sequencing has revealed remarkable cellular heterogeneity, the lack of spatial context limits our underst ...

EPFL2025

Spotiflow: accurate and efficient spot detection for fluorescence microscopy with deep stereographic flow regression

Joachim Lingner, Suliana Manley, Gioele La Manno, Can Aztekin, Irina Khven, Eftychia Kyriacou, Albert Dominguez Mantes, Evangelia Skoufa, Martin Weigert, Georgios Tsissios

Identification of spot-like structures in large, noisy microscopy images is a crucial step for many life-science applications. Imaging-based spatial transcriptomics (iST), in particular, relies on the precise detection of millions of transcripts in low sig ...

2025