Concept

3D bioprinting

Related publications (81)

Pore Size Manipulation in 3D Printed Cryogels Enables Selective Cell Seeding

Philippe Renaud, Arnaud Bertsch, Thomas Michael Braschler, Ariane Rochat, Amélie Barbara Hildegarde Béduer, Ludovic Serex, Aleksandra Filippova

Cryogels are macroporous materials that display remarkable properties, such as high pore interconnection, large surface to volume ratio, and high mechanical stability, making them good candidates for 3D cell culture. However, shaping cryogels remains chall ...

2018

Development of functionalized alginate-based hydrogels to reduce fibrosis in the transplantation of microencapsulated cells

François Rémi Pierre Noverraz

Nowadays, the development of cell therapy relies mainly on the advances made toward cell microencapsulation which allows to evade the need for immunosuppression during cell transplantation. Among the materials considered for cell encapsulation, hydrogels d ...

EPFL2018

Natural polymer-derived scaffold material and methods for production thereof

Matthias Lütolf, Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, Elif Vardar, Kalitha Pinnagoda, Simone Allazetta, Eva-Maria Balet

The invention relates to a scaffold material comprising a carrier and embedded microbeads for use in tissue engineering applications such as soft tissues therapeutic treatment. The scaffold provides a short-term bulking effect coupled with a long-term func ...

2017

Shapeable scaffold material and uses thereof

Philippe Renaud, Thomas Michael Braschler, Amélie Barbara Hildegarde Béduer, Giorgio Pietramaggiori

The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material imp ...

2017

Difference in suitable mechanical properties of three-dimensional, synthetic scaffolds for self-renewing mouse embryonic stem cells of different genetic backgrounds

Jeffrey Alan Hubbell, Seung Tae Lee

We evaluated whether the genetic background of embryonic stem cells (ESCs) affects the properties suitable for three-dimensional (3D) synthetic scaffolds for cell self-renewal. Inbred R1 and hybrid B6D2F1 mouse ESC lines were cultured for 7 days in hydroge ...

Wiley2017

Advanced technologies to control stem-cell based organogenesis

Nathalie Brandenberg

Organoids represent the first in vitro cell culture systems that closely resemble native tissues in terms of cellular composition, architecture and key aspects of physiology. Through the discovery of these cultures, researchers could demonstrate that stem ...

EPFL2017

IGF-1-containing multi-layered collagen-fibrin hybrid scaffolds for bladder tissue engineering

Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, Priscilla Suhasna Maithili Briquez, Elif Vardar, Kalitha Pinnagoda

Clinical success of bladder reconstructive procedures could be promoted by the availability of functional biomaterials. In this study, we have developed a multi-layered scaffold consisting of a bioactive fibrin layer laminated between two collagen sheets a ...

Elsevier Sci Ltd2016

Bioprinting the Cancer Microenvironment

Margaux Catherine Marie Duchamp

Cancer is intrinsically complex, comprising both heterogeneous cellular compositions and microenvironmental cues. During the various stages of cancer initiation, development, and metastasis, cell-cell interactions (involving vascular and immune cells besid ...

Amer Chemical Soc2016

Nano Fibrillated Cellulose Based Composite Hydrogels for an Injectable Intervertebral Disc Implant

Azadeh Khoushabi

Replacing the gel-like central part of the intervertebral disc (IVD), so-called nucleus pulposus (NP), via a minimally invasive surgery is one of the most recent approaches in the lower back pain treatments. An appropriate biomaterial for NP replacement (N ...

EPFL2016

Tunable and cell-responsive 3D poly(ethylene glycol) microenvironments for the development of tissue models

Stéphanie Elisabeth Metzger

The recapitulation of tissue organization and function in vitro is one of the main objectives of tissue engineering. Proper tissue function depends on the spatial assembly and interactions between key components such as cells, growth factors, signaling cue ...

EPFL2016

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