Publications related to Cancer epigenetics

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Alessandra Piersigilli, Adrienne Joëlle Laurence Mottis, Keir Joe Menzies, Hiroyasu Yamamoto, Giuseppe Lo Sasso

Background: SIRT2 belongs to a highly conserved family of NAD(+)-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes. Recent ...

Public Library of Science2014

TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres

Joachim Lingner, Antonio Porro, Sascha Feuerhahn

Telomeres protect chromosome ends from being recognized as sites of DNA damage. Upon telomere shortening or telomere uncapping induced by loss of telomeric repeat-binding factor 2 (TRF2), telomeres elicit a DNA-damage response leading to cellular senescenc ...

Elsevier2014

Dynamic Persistence of Antibiotic-Stressed Mycobacteria

John McKinney, Neeraj Dhar, François Signorino-Gelo, Katrin Esther Schneider

Exposure of an isogenic bacterial population to a cidal antibiotic typically fails to eliminate a small fraction of refractory cells. Historically, fractional killing has been attributed to infrequently dividing or nondividing "persisters." Using microflui ...

Amer Assoc Advancement Science2013

Histone H3 K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes

Beat Fierz, Zhipeng Tang

Trimethylated histone H3 lysine 4 (H3K4) and H3K27 generally mark transcriptionally active and repressive chromatins, respectively. In most cell types, these two modifications are mutually exclusive and this segregation is crucial for the regulation of gen ...

American Society for Microbiology2013

Notch1 Is Required for Kras-Induced Lung Adenocarcinoma and Controls Tumor Cell Survival via p53

Freddy Radtke

The Notch pathway has been implicated in a number of malignancies with different roles that are cell- and tissue-type dependent. Notch1 is a putative oncogene in non-small cell lung cancer (NSCLC) and activation of the pathway represents a negative prognos ...

American Association for Cancer Research2013

Metabolic Characterization of a Sirt5 deficient mouse model

Johan Auwerx, Kristina Schoonjans, Norman Lionel Moullan, Lilia Noriega Lopez, Jiujiu Yu

Sirt5, localized in the mitochondria, is a member of sirtuin family of NAD(+)-dependent deacetylases. Sirt5 was shown to deacetylate and activate carbamoyl phosphate synthase 1. Most recently, Sirt5 was reported to be the predominant protein desuccinylase ...

Nature Publishing Group2013

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

Jocelyne Bloch, Mauro Delorenzi

The methylation status of the O-6-methylguanine-DNA methyltransferase (MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma. Recent studies in anaplastic glioma suggest a prognostic value for MGMT methyl ...

Springer-Verlag2012

Single walled carbon nanotubes as drug delivery vehicles: Targeting doxorubicin to tumors

Paul Joseph Dyson, Zhaofu Fei, Xianfu Zhang

Single walled carbon nanotubes (SWNTs) are emerging as promising delivery vehicles for cancer diagnostics and chemotherapies due to their unique properties, including, remarkable cell membrane penetrability, high drug-carrying capacities, pH-dependent ther ...

2012

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Cancer epigenetics

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres

Dynamic Persistence of Antibiotic-Stressed Mycobacteria

Histone H3 K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes

Histone acetylation: molecular mnemonics on the chromatin

Notch1 Is Required for Kras-Induced Lung Adenocarcinoma and Controls Tumor Cell Survival via p53

Metabolic Characterization of a Sirt5 deficient mouse model

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

Cell biology: a key driver of therapeutic innovation

Single walled carbon nanotubes as drug delivery vehicles: Targeting doxorubicin to tumors

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Chat with Graph Search

Histone H3 K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

Dynamic Persistence of Antibiotic-Stressed Mycobacteria

TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres

Notch1 Is Required for Kras-Induced Lung Adenocarcinoma and Controls Tumor Cell Survival via p53

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

Metabolic Characterization of a Sirt5 deficient mouse model

Single walled carbon nanotubes as drug delivery vehicles: Targeting doxorubicin to tumors

Cell biology: a key driver of therapeutic innovation