Polysubstance use

Polysubstance use or poly drug use refers to the use of combined psychoactive substances. Polysubstance use may be used for entheogenic, recreational, or off-label indications, with both legal and illegal substances. In many cases one drug is used as a base or primary drug, with additional drugs to leaven or compensate for the side effects, or tolerance, of the primary drug and make the experience more enjoyable with drug synergy effects, or to supplement for primary drug when supply is low. List of polysubstance combinations The most common psychoactive substances are alcohol, caffeine, cannabis, and nicotine (tobacco, and nicotine replacement therapy). Some of the absolutely most common polysubstance combinations are: Alcohol combined with cannabis — known as cross-fading and may easily cause spins in people who are drunk and smoke potent cannabis. Ayahuasca: DMT combined with MAOIs. Caffeinated alcoholic drinks Some of the absolutely most common combination drugs used recreationally are: Dimenhydrinate (8-chlorotheophylline/diphenhydramine) — used to treat motion sickness and nausea Adderall (dextroamphetamine sulfate/amphetamine sulfate/dextroamphetamine saccharate/amphetamine aspartate monohydrate) — treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Some substances, such as the powerful psychedelic drug DMT, are not psychoactive when ingested alone. Ayahuasca, or pharmahuasca, notably consists of DMT combined with MAOIs that interfere with the action of the MAO enzyme and stop the breakdown in the stomach of chemical compounds, which make the DMT psychoactive. The MAOIs are also psychoactive and thus produce a polysubstance effect with the DMT. However, the MAOIs may cause combined drug intoxication with the majority of all psychoactive substances and are therefore usually only combined with DMT. TOMSO is a lesser-known psychedelic drug and a substituted amphetamine. TOMSO is inactive on its own; it is activated with the consumption of alcohol.