Concept

Overlapping gene

Related publications (235)

Dissecting the brown adipogenic regulatory network using integrative genomics

Bart Deplancke, Vincent Roland Julien Gardeux, Julie Marie Russeil, Johannes Julius Bues, Daniel Alpern, Sunil Kumar Raghav, Petra Catalina Schwalie, Wanze Chen, Rachana Narendra Pradhan

Brown adipocytes regulate energy expenditure via mitochondrial uncoupling, which makes them attractive therapeutic targets to tackle obesity. However, the regulatory mechanisms underlying brown adipogenesis are still poorly understood. To address this, we ...

Springer Nature2017

Toward the identification of cellular mechanisms behind the lethal phenotypes in Plasmodium berghei blood stages with PlasmoGEM and metabolic modeling

Vassily Hatzimanikatis

Recent advances in cell genome editing techniques enable the generation of high-throughput gene knockout data in the malaria parasites in vivo. Integrative analysis of this data can lead to the identification of biological mechanisms that explain the obser ...

2017

Bicistronic aav vector for rna interference in als

Bernard Schneider, Cylia Cloé Rochat

The present invention relates to a bicistronic expression vector for silencing a gene specifically in astrocytes and neurons, comprising two expression cassettes comprising a first and a second silencer sequence, respectively, wherein the expression of sai ...

2017

Unraveling the KRAB/KAP1 control of transposable elements in pluripotent and somatic cells

Gabriela Ecco

Transposable elements (TEs) are DNA sequences able to change position in the genome, and represent more than 40% of mammalian genetic material. TEs can have positive or detrimental effects on the host, being both important motors of evolution and genomic t ...

EPFL2016

The Gene Family-Free Median of Three

Metin Balaban

The gene family-free framework for comparative genomics aims at developing methods for gene order analysis that do not require prior gene family assignment, but work directly on a sequence similarity graph. We present a model for constructing a median of t ...

Springer AG2016

An Optimization Based Coupling Method For Multiscale Problems

Assyr Abdulle, Alexander Shapeev

A new multiscale coupling method is proposed for elliptic problems with highly oscillatory coefficients with a continuum of scales in a subset of the computational domain and scale separation in complementary regions of the computational domain. A disconti ...

Society for Industrial and Applied Mathematics2016

The Interface Control Domain Decomposition Method For Stokes-Darcy Coupling

Alfio Quarteroni, Marco Discacciati

The interface control domain decomposition (ICDD) method of Discacciati, Gervasio, and Quarteroni [SIAM J. Control Optim., 51 (2013), pp. 3434-3458, doi:10.1137/120890764; J. Coupled Syst. Multiscale Dyn., 1 (2013), pp. 372-392, doi:10.1166/jcsmd.2013.1026 ...

Siam Publications2016

Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species Complex

Marianna Feretzaki

RNAi is a ubiquitous pathway that serves central functions throughout eukaryotes, including maintenance of genome stability and repression of transposon expression and movement. However, a number of organisms have lost their RNAi pathways, including the mo ...

Public Library of Science2016

Genetic characterization of an adapted pandemic 2009 H1N1 influenza virus that reveals improved replication rates in human lung epithelial cells

Christian Sieben

The 2009 influenza pandemic originated from a swine-origin H1N1 virus, which, although less pathogenic than anticipated, may acquire additional virulence-associated mutations in the future. To estimate the potential risk, we sequentially passaged the isola ...

Academic Press Inc Elsevier Science2016

Integrating Transcriptomic Data with Thermodynamically Consistent Metabolic Models

Vikash Kumar Pandey, Daniel Federico Hernandez Gardiol

In metabolic modeling, experimental data is used to constrain the solution space of allowable flux distributions to biologically feasible phenotypes. This makes metabolic modeling a powerful tool for integrating information from different experimental sour ...

2015

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