Publications related to Common gamma chain

PD-1-cis IL-2R agonism yields better effectors from stem-like CD8(+) T cells

Douglas Hanahan, Mélanie Louise Tichet, Petra Catalina Schwalie, Stephan Wullschleger, Maria Karagianni

Expansion and differentiation of antigen-experienced PD-1(+)TCF-1(+) stem-like CD8(+) T cells into effector cells is critical for the success of immunotherapies based on PD-1 blockade(1-4). Hashimoto et al. have shown that, in chronic infections, administr ...

NATURE PORTFOLIO2022

Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder

Dylan Lawless, Beibei Wu

CRAC channel regulator 2 A (CRACR2A) is a large Rab GTPase that is expressed abundantly in T cells and acts as a signal transmitter between T cell receptor stimulation and activation of the Ca2+-NFAT and JNK-AP1 pathways. CRACR2A has been linked to human d ...

eLIFE SCIENCES PUBL LTD2021

Boosted Pro-Inflammatory Activity in Human PBMCs by Lipopolysaccharide and SARS-CoV-2 Spike Protein Is Regulated by alpha-1 Antitrypsin

Florian Maria Wurm, Divor Kiseljak

For the treatment of severe COVID-19, supplementation with human plasma-purified alpha-1 antitrypsin (AAT) to patients is currently considered. AAT inhibits host proteases that facilitate viral entry and possesses broad anti-inflammatory and immunomodulato ...

MDPI2021

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions

Nicola Harris, Julia Esser-von Bieren, Tiffany Babette Angélique Bouchery

Background Eicosanoid lipid mediators play key roles in type 2 immune responses, for example in allergy and asthma. Macrophages represent major producers of eicosanoids and they are key effector cells of type 2 immunity. We aimed to comprehensively track e ...

WILEY2019

Signalling strength determines proapoptotic functions of STING

Freddy Radtke, Andrea Ablasser, Ute Koch, Muhammet Fatih Gülen

Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS-STING signalling pathway, which initiates a gene expression programme linked to ce ...

Springer Nature2017

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

Johan Auwerx, Tytti Heinonen

Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox homeostasis, and protects from aging and age-associated pathologies. SIRT3 may drive both oncogenic and tumor-suppressive effects. SIRT3 deficiency has been ...

Nature Publishing Group2017

Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection

Johan Auwerx, Tytti Heinonen, Marc Pfefferlé

Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD(+)-dependent histone deacetylases. Sirtuins target histones and non-histone proteins according to their subcellular localization, influencing various biological processes. SIRT2 resides mai ...

Frontiers Media Sa2017

Parasite Proximity Drives the Expansion of Regulatory T Cells in Peyer's Patches following Intestinal Helminth Infection

Nicola Harris, Mario Michael Zaiss, Beatrice Volpe, Julia Esser-von Bieren, Ilaria Mosconi, Lalit Kumar Dubey, Luc Xavier Marie Lebon

Helminth infections are typically chronic in nature; however, the exact molecular mechanisms by which these parasites promote or thwart host immunity remain unclear. Worm expulsion requires the differentiation of CD4(+) T cells into Th2 cells, while regula ...

American Society for Microbiology2015

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Common gamma chain

PD-1-cis IL-2R agonism yields better effectors from stem-like CD8(+) T cells

Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder

Boosted Pro-Inflammatory Activity in Human PBMCs by Lipopolysaccharide and SARS-CoV-2 Spike Protein Is Regulated by alpha-1 Antitrypsin

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions

Signalling strength determines proapoptotic functions of STING

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection

ESCRT proteins restrict constitutive NF-kappa B signaling by trafficking cytokine receptors

Parasite Proximity Drives the Expansion of Regulatory T Cells in Peyer's Patches following Intestinal Helminth Infection

Improving Immunogenicity of Subunit Vaccines Using Nanocarrier Systems

Graph Chatbot

Chat with Graph Search

Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder

ESCRT proteins restrict constitutive NF-kappa B signaling by trafficking cytokine receptors

Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection

PD-1-cis IL-2R agonism yields better effectors from stem-like CD8(+) T cells

Boosted Pro-Inflammatory Activity in Human PBMCs by Lipopolysaccharide and SARS-CoV-2 Spike Protein Is Regulated by alpha-1 Antitrypsin

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

Parasite Proximity Drives the Expansion of Regulatory T Cells in Peyer's Patches following Intestinal Helminth Infection

Improving Immunogenicity of Subunit Vaccines Using Nanocarrier Systems

Signalling strength determines proapoptotic functions of STING