Concept
Common gamma chain
Publications associées (38)
PD-1-cis IL-2R agonism yields better effectors from stem-like CD8(+) T cells
Douglas Hanahan, Mélanie Louise Tichet, Petra Catalina Schwalie, Stephan Wullschleger, Maria Karagianni
Expansion and differentiation of antigen-experienced PD-1(+)TCF-1(+) stem-like CD8(+) T cells into effector cells is critical for the success of immunotherapies based on PD-1 blockade(1-4). Hashimoto et al. have shown that, in chronic infections, administr ...
NATURE PORTFOLIO2022Boosted Pro-Inflammatory Activity in Human PBMCs by Lipopolysaccharide and SARS-CoV-2 Spike Protein Is Regulated by alpha-1 Antitrypsin
Florian Maria Wurm, Divor Kiseljak
For the treatment of severe COVID-19, supplementation with human plasma-purified alpha-1 antitrypsin (AAT) to patients is currently considered. AAT inhibits host proteases that facilitate viral entry and possesses broad anti-inflammatory and immunomodulato ...
MDPI2021House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions
Nicola Harris, Julia Esser-von Bieren, Tiffany Babette Angélique Bouchery
Background Eicosanoid lipid mediators play key roles in type 2 immune responses, for example in allergy and asthma. Macrophages represent major producers of eicosanoids and they are key effector cells of type 2 immunity. We aimed to comprehensively track e ...
WILEY2019Signalling strength determines proapoptotic functions of STING
Freddy Radtke, Andrea Ablasser, Ute Koch, Muhammet Fatih Gülen
Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS-STING signalling pathway, which initiates a gene expression programme linked to ce ...
Springer Nature2017Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections
Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox homeostasis, and protects from aging and age-associated pathologies. SIRT3 may drive both oncogenic and tumor-suppressive effects. SIRT3 deficiency has been ...
Nature Publishing Group2017