Publications related to Latent autoimmune diabetes in adults

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

Stephane Kontos, Jeffrey Alan Hubbell, Iraklis Kourtis, Karen Dane

Antigens derived from apoptotic cell debris can drive clonal T-cell deletion or anergy, and antigens chemically coupled ex vivo to apoptotic cell surfaces have been shown correspondingly to induce tolerance on infusion. Reasoning that a large number of ery ...

Natl Acad Sciences2013

Comparative Performance of Different Nanostructured Electrochemical Sensors on Insulin Detection

Giovanni De Micheli, Sandro Carrara, Lucia Grassi

New advancements in the management of type I diabetic patients (T1DM) call for a new generation of monitoring systems based upon an array of metabolic biosensors including sensors for insulin detection. Blood insulin values are always less than 270 pM; the ...

2013

Restoration of direct pathway glycogen synthesis flux in the STZ-diabetes rat model by insulin administration

Ana Francisca Leal Silva Soares

Type 1 diabetes subjects are characterized by impaired direct pathway synthesis of hepatic glycogen that is unresponsive to insulin therapy. Since it is not known whether this is an irreversible defect of insulin-dependent diabetes, direct and indirect pat ...

2012

A Minimal Exercise Extension for Models of the Glucoregulatory System

Denis Gillet, Grégory François, Alain Bock, Thierry Prud'Homme

For patients with type 1 diabetes mellitus, appropriate control of blood glucose concentrations is vital. Exercise is one of the disturbances that can affect these concentrations. Therefore, predictions in the presence of exercise are useful among others f ...

Elsevier2011

Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia

Daniel Constam, Marine Marie Kraus, Anne Grapin-Botton

Bicaudal C homologue 1 (Bicc1) knockout in mice causes polycystic kidney disease and pancreas development defects, including a reduction in insulin-producing β-cells and ensuing diabetes. We therefore screened 137 patients with renal abnormalities or assoc ...

2011

JewelPUMP (TM) by Debiotech S.A.: Insulin Temperature Measurement Study

Adrien De Muralt

For type 1 Diabetes, insulin injection therapy is the most used treatment today, and insulin pumps are surely the most accurate therapeutic strategy. The insulin use temperature has to not exceed 37°C to prevent unwanted degradation and loss of function. T ...

2011

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Johan Auwerx, Kristina Schoonjans, Thijs Pols

Incretin-based therapies have shown promise in the treatment of type 2 diabetes. Here we review our current understanding of TGR5 as a target to induce glucagon-like peptide-1 (GLP-1) secretion. These new observations suggest that TGR5 agonists may constit ...

Elsevier Masson2010

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

Philipp Bucher

OBJECTIVE: Pancreatic islets of perinatal mice lacking the transcription factor Rfx3 exhibit a marked reduction in insulin-producing beta-cells. The objective of this work was to unravel the cellular and molecular mechanisms underlying this deficiency. RES ...

American Diabetes Association2010

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

Rolf Gruetter, João Miguel das Neves Duarte

Type 1 diabetes can affect hippocampal function triggering cognitive impairment through unknown mechanisms. Caffeine consumption prevents hippocampal degeneration and memory dysfunction upon different insults and is also known to affect peripheral glucose ...

Wiley-Blackwell2009

Latent autoimmune diabetes in adults

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Engineering antigens for in situ erythrocyte binding induces T-cell deletion

Comparative Performance of Different Nanostructured Electrochemical Sensors on Insulin Detection

Restoration of direct pathway glycogen synthesis flux in the STZ-diabetes rat model by insulin administration

A Minimal Exercise Extension for Models of the Glucoregulatory System

Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia

JewelPUMP (TM) by Debiotech S.A.: Insulin Temperature Measurement Study

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

Restoration of direct pathway glycogen synthesis flux in the STZ-diabetes rat model by insulin administration

Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia

Comparative Performance of Different Nanostructured Electrochemical Sensors on Insulin Detection

JewelPUMP (TM) by Debiotech S.A.: Insulin Temperature Measurement Study

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

A Minimal Exercise Extension for Models of the Glucoregulatory System