Concept

Thioester

Related publications (32)

Highly Enantioselective Rhodium(I)-Catalyzed Carbonyl Carboacylations Initiated by C-C Bond Activation

Nicolai Cramer, Laetitia Marie Mélanie Souillart

The lactone motif is ubiquitous in natural products and pharmaceuticals. The Tishchenko disproportionation of two aldehydes, a carbonyl hydroacylation, is an efficient and atom-economic access to lactones. However, these reaction types are limited to the t ...

Wiley-Blackwell2014

Functionalized Carbon Nanostructures from Oligoyne Carboxylates

Stephen Schrettl

Functional nanostructured carbon materials, including two-dimensionally extended nanosheets, offer intriguing perspectives for applications in emerging technologies such as hydrogen storage, lithium storage, transition metal free catalysis, or solar abso ...

EPFL2014

Synthesis, molecular structure, computational study and in vitro anticancer activity of dinuclear thiolato-bridged pentamethylcyclopentadienyl Rh(III) and Ir(III) complexes

Paul Joseph Dyson, Benjamin Samuel Murray

Neutral dinuclear dithiolato-bridged pentamethylcyclopentadienyl Rh(III) complexes of the type (C5Me5)(2)Rh-2(mu-SR)(2)Cl-2 (R = CH2Ph, 1; R = CH2CH2Ph, 2) and cationic dinuclear trithiolato-bridged pentamethylcyclopentadienyl Rh(III) and Ir(III) complexes ...

Royal Society of Chemistry2013

Development of New Bicyclic Peptide Formats and their Application in Directed Evolution

Shiyu Chen

Cyclic peptides have a range of properties that make them attractive as therapeutics such as high binding affinity, good target selectivity and low toxicity. While most peptides in the clinic are derived from nature, various powerful in vitro evolution tec ...

EPFL2013

Thiolato-bridged arene-ruthenium complexes: synthesis, molecular structure, reactivity and anticancer activity of the dinuclear complexes [(arene)2Ru2(SR)2C12]

Paul Joseph Dyson, Olivier Pierre Zava

Treatment of an areneruthenium dichloride dimer with thiols RSH to lead to cationic trithiolato complexes of the type [(arene)2Ru2(SR)3]+ was shown to proceed through the neutral thiolato complexes [(arene)2Ru2(SR)2Cl2], which have been isolated and charac ...

Wiley-Blackwell2012

Structurally Diverse Cyclisation Linkers Impose Different Backbone Conformations in Bicyclic Peptides

Christian Heinis, Alessandro Angelini, Shiyu Chen, Julia Morales Sanfrutos

Combinatorial libraries of structurally diverse peptide macrocycles offer a rich source for the development of high-affinity ligands to targets of interest. In this work we have developed linkers for the generation of genetically encoded bicyclic peptides ...

2012

A DEMS study of methanol and formic acid oxidation on boron-doped diamond electrode

Christos Comninellis, György Foti, Agnieszka Kapalka

The electrochemical oxidation of methanol and formic acid in 1 M HClO4 is studied on boron-doped diamond electrode using differential electrochemical mass spectrometry (DEMS). DEMS is used to identify products and intermediates of the reaction monitored on ...

2009

One-step refolding and purification of disulfide-containing proteins with a C-terminal MESNA thioester

Maartje Martina Cornelia Bastings

Background Expression systems based on self-cleavable intein domains allow the generation of recombinant proteins with a C-terminal thioester. This uniquely reactive C-terminus can be used in native chemical ligation reactions to introduce synthetic groups ...

BioMed Central2008

Synthesis of poly(PEGA) Bioconjugates using RAFT Polymerization

Emmanuelle Bays

Protein-polymer conjugates are widely used in biotechnology and medicine, and non-toxic polymers for bioconjugation would be advantageous for these applications. Herein, we reported the toxicity of polymers synthesized by two commonly employed controlled r ...

2008

RNA-sequence or nucleoside/nucleotide analogues and method for producing the analogues

Sébastien Porcher

Nucleic acid sequence analogues, in particular tRNA analogues comprising in the place of a 3'-terminal adenosine a 3'-terminal 2'-deoxy-2'-thioadenosine are able to react site-specifically with weakly activated amino acid derivatives (e.g. phenylthioesters ...

2006

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