Concept
Virus latency
Related publications (32)
Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier
Gerardo Turcatti, Marc Chambon, Damiano Banfi, Jonathan Patrice Vesin
Multiple enveloped RNA viruses of the family Paramyxoviridae and Pneumoviridae, like measles virus (MeV), Nipah virus (NiV), canine distemper virus (CDV), or respiratory syncytial virus (RSV), are of high clinical relevance. Each year a huge number of live ...
AMER SOC MICROBIOLOGY2021HIV host genomics in the era of effective antiretroviral therapy
Christian Axel Wandall Thorball
The introduction and widespread use of antiretroviral therapy against Human Immunodefi-ciency Virus (HIV) has had a remarkable effect on disease progression and the longevity of infected individuals. However, the establishment of a latent viral reservoir a ...
EPFL2020Viral Metagenomic Content Reflects Seawater Ecological Quality in the Coastal Zone
Grégoire Marie Octave Edouard Michoud, Stylianos Fodelianakis
Viruses interfere with their host's metabolism through the expression of auxiliary metabolic genes (AMGs) that, until now, are mostly studied under large physicochemical gradients. Here, we focus on coastal marine ecosystems and we sequence the viral metag ...
2020Sulfonated Nanomaterials with Broad-Spectrum Antiviral Activity Extending beyond Heparan Sulfate-Dependent Viruses
Francesco Stellacci, Valeria Cagno, Matteo Gasbarri, Chiara Medaglia
Viral infections are among the main causes of death worldwide, and we lack antivirals for the majority of viruses. Heparin-like sulfated or sulfonated compounds have been known for decades for their ability to prevent infection by heparan sulfate proteogly ...
AMER SOC MICROBIOLOGY2020Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART
Jacques Fellay, Christian Axel Wandall Thorball, Alessandro Borghesi
The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population ...
Springer2019