Publications associées à Virus latency

Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier

Gerardo Turcatti, Marc Chambon, Damiano Banfi, Jonathan Patrice Vesin

Multiple enveloped RNA viruses of the family Paramyxoviridae and Pneumoviridae, like measles virus (MeV), Nipah virus (NiV), canine distemper virus (CDV), or respiratory syncytial virus (RSV), are of high clinical relevance. Each year a huge number of live ...

AMER SOC MICROBIOLOGY2021

Modified cyclodextrins as broad-spectrum antivirals

Francesco Stellacci, Natalia Gasilova, Valeria Cagno, Matteo Gasbarri, Samuel Thomas Jones, Matej Janecek

Viral infections kill millions of people and new antivirals are needed. Nontoxic drugs that irreversibly inhibit viruses (virucidal) are postulated to be ideal. Unfortunately, all virucidal molecules described to date are cytotoxic. We recently developed n ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Viral Metagenomic Content Reflects Seawater Ecological Quality in the Coastal Zone

Grégoire Marie Octave Edouard Michoud, Stylianos Fodelianakis

Viruses interfere with their host's metabolism through the expression of auxiliary metabolic genes (AMGs) that, until now, are mostly studied under large physicochemical gradients. Here, we focus on coastal marine ecosystems and we sequence the viral metag ...

2020

Initial Step of Virus Entry: Virion Binding to Cell-Surface Glycans

Laurent Gillet, Christian Sieben

Virus infection is an intricate process that requires the concerted action of both viral and host cell components. Entry of viruses into cells is initiated by interactions between viral proteins and cell-surface receptors. Various cell-surface glycans func ...

ANNUAL REVIEWS2020

Sulfonated Nanomaterials with Broad-Spectrum Antiviral Activity Extending beyond Heparan Sulfate-Dependent Viruses

Francesco Stellacci, Valeria Cagno, Matteo Gasbarri, Chiara Medaglia

Viral infections are among the main causes of death worldwide, and we lack antivirals for the majority of viruses. Heparin-like sulfated or sulfonated compounds have been known for decades for their ability to prevent infection by heparan sulfate proteogly ...

AMER SOC MICROBIOLOGY2020

Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART

Jacques Fellay, Chenjie Wan

The HIV-1 reservoir is the major hurdle to curing HIV-1. However, the impact of the viral genome on the HIV-1 reservoir, i.e. its heritability, remains unknown. We investigate the heritability of the HIV-1 reservoir size and its long-term decay by analyzin ...

NATURE RESEARCH2020

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

Jacques Fellay, Christian Axel Wandall Thorball, Alessandro Borghesi

The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population ...

Springer2019

E-coli-MS2 bacteriophage interactions during solar disinfection of wastewater and the subsequent post-irradiation period

César Pulgarin, Anna Carratala Ripolles, Stefanos Giannakis

In this study, the effect of MS2 bacteriophage on the inactivation of its Escherichia coli host was evaluated in an effort to recreate some the main factors governing solar disinfection of wastewater (namely microbial growth, infection, photonic flux). As ...

ELSEVIER SCIENCE SA2019

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Francesco Stellacci, Paulo Henrique Jacob Silva, Ahmet Bekdemir, Valeria Cagno, Emma-Rose Janecek, Samuel Thomas Jones, Marie Mueller

Viral infections kill millions yearly. Available antiviral drugs are virus-specific and active against a limited panel of human pathogens. There are broad-spectrum substances that prevent the first step of virus–cell interaction by mimicking heparan sulfat ...

2018

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Virus latency

Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier

HIV host genomics in the era of effective antiretroviral therapy

Modified cyclodextrins as broad-spectrum antivirals

Viral Metagenomic Content Reflects Seawater Ecological Quality in the Coastal Zone

Initial Step of Virus Entry: Virion Binding to Cell-Surface Glycans

Sulfonated Nanomaterials with Broad-Spectrum Antiviral Activity Extending beyond Heparan Sulfate-Dependent Viruses

Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

E-coli-MS2 bacteriophage interactions during solar disinfection of wastewater and the subsequent post-irradiation period

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Graph Chatbot

Chattez avec Graph Search

Initial Step of Virus Entry: Virion Binding to Cell-Surface Glycans

Modified cyclodextrins as broad-spectrum antivirals

Viral Metagenomic Content Reflects Seawater Ecological Quality in the Coastal Zone

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Sulfonated Nanomaterials with Broad-Spectrum Antiviral Activity Extending beyond Heparan Sulfate-Dependent Viruses

Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier

E-coli-MS2 bacteriophage interactions during solar disinfection of wastewater and the subsequent post-irradiation period

Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART

HIV host genomics in the era of effective antiretroviral therapy

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART