Publications related to Lac repressor

Composition of the DNA-uptake complex of Vibrio cholerae

Melanie Blokesch, Lisa Christina Metzger

Natural competence for transformation is a developmental program that allows certain bacteria to take up free extracellular DNA from the environment and integrate this DNA into their genome. Thereby, natural transformation acts as mode of horizontal gene t ...

2014

Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

Didier Trono, Bart Deplancke, Sebastian Martin Waszak, Sunil Kumar Raghav, Petra Catalina Schwalie, Andrea Corsinotti, Gilles Udin

Adipose tissue is a key determinant of whole body metabolism and energy homeostasis. Unraveling the regulatory mechanisms underlying adipogenesis is therefore highly relevant from a biomedical perspective. Our current understanding of fat cell differentiat ...

Elife Sciences Publications Ltd2014

Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription

Felix Naef, Sebastian Maerkl, Jacques Rougemont, Nicolas Dénervaud, Marcel Geertz, Philippe Jacquet

In yeast, ribosome production is controlled transcriptionally by tight coregulation of the 138 ribosomal protein genes (RPGs). RPG promoters display limited sequence homology, and the molecular basis for their coregulation remains largely unknown. Here we ...

Cold Spring Harbor Laboratory Press2014

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

Didier Trono, Jiri Vanicek, Isabelle Barde, Sonia Verp, Sandra Eloise Kjeldsen, Adamantia Kapopoulou, Andrea Corsinotti, Ray Marcel Marin Florez, Benjamin Rauwel

During hematopoiesis, lineage- and stage-specific transcription factors work in concert with chromatin modifiers to direct the differentiation of all blood cells. Here, we explored the role of KRAB-containing zinc finger proteins (KRAB-ZFPs) and their cofa ...

Amer Assoc Advancement Science2013

iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks

Bart Deplancke, Sebastian Maerkl, Marcel Geertz, Sylvie Rockel

Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic ...

Oxford University Press2013

MAR-mediated integration of plasmid vectors for in vivo gene transfer and regulation

Andrzej Kulik, Nicolas Mermod, Stefania Puttini, Déborah Ley, Damien Saugy

Background: The in vivo transfer of naked plasmid DNA into organs such as muscles is commonly used to assess the expression of prophylactic or therapeutic genes in animal disease models. Results: In this study, we devised vectors allowing a tight regulatio ...

BioMed Central2013

The Kruppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo

Didier Trono, Isabelle Barde, Sonia Verp, Sandra Eloise Kjeldsen, Anna Claire Groner

The study of chromatin and its regulators is key to understanding and manipulating transcription. We previously exploited the Krüppel-associated box (KRAB) transcriptional repressor domain, present in hundreds of vertebrate-specific zinc finger proteins, t ...

2012

KAP1 regulates gene networks controlling T-cell development and responsiveness

Didier Trono, Isabelle Barde, Nicola Harris, Sandra Eloise Kjeldsen, Adamantia Kapopoulou, Andrea Corsinotti, Karolina Bojkowska

Chromatin remodeling at specific genomic loci controls lymphoid differentiation. Here, we investigated the role played in this process by Kruppel-associated box (KRAB)-associated protein 1 (KAP1), the universal cofactor of KRAB-zinc finger proteins (ZFPs), ...

Federation Amer Soc Exp Biol2012

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Lac repressor

Composition of the DNA-uptake complex of Vibrio cholerae

Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

Systematic Analysis of Yeast Gene Expression by Synthetic Promoter Libraries

iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks

MAR-mediated integration of plasmid vectors for in vivo gene transfer and regulation

HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration

The Kruppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo

KAP1 regulates gene networks controlling T-cell development and responsiveness

Graph Chatbot

Chat with Graph Search

Composition of the DNA-uptake complex of Vibrio cholerae

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription

HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration

Systematic Analysis of Yeast Gene Expression by Synthetic Promoter Libraries

The Kruppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo

iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks

MAR-mediated integration of plasmid vectors for in vivo gene transfer and regulation

KAP1 regulates gene networks controlling T-cell development and responsiveness