Publications related to Pancreas

Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis

Anne Grapin-Botton, Mathieu Gouzi, Cédric Cortijo

Planar cell polarity (PCP) refers to the collective orientation of cells within the epithelial plane. We show that progenitor cells forming the ducts of the embryonic pancreas express PCP proteins and exhibit an active PCP pathway. Planar polarity proteins ...

Cell Press2012

Planar Cell Polarity Controls Pancreatic Endocrine Differentiation

Cédric Cortijo

PCP proteins are restricted to progenitor cells in the embryonic pancreas. The PCP core components Celsr2/3 control endocrine cell differentiation. This effect is mediated by the JNK pathway ...

EPFL2012

Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival

Emilie Gesina

The absence of the transcriptional repressor RE-1 Silencing Transcription Factor (REST) in insulin-secreting beta cells is a major cue for the specific expression of a large number of genes. These REST target genes were largely ascribed to a function of ne ...

Public Library of Science2012

GLUT2-/- mice are resistant to age-induced accumulation of fat in the liver – an in vivo MRS study

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

Introduction: Whole-body energy balance is strongly dependent on the hepatic handling of metabolic fuels, which is affected by the hepatic lipid content (HLC). With in vivo nuclear magnetic resonance spectroscopy (MRS) HLC can be measured non-invasively an ...

Wiley-Blackwell2012

Diabetes imaging — quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy

Dimitri Nestor Alice Van De Ville, Theo Lasser, Anthony Christopher Davison, Anne Grapin-Botton, Martin Villiger, Arno Pino Bouwens, Corinne Berclaz, Joan Goulley, Erica Martin-Williams

Diabetes is characterized by hyperglycemia that can result from the loss of pancreatic insulin secreting β-cells in the islets of Langerhans. We analyzed ex vivo the entire gastric and duodenal lobes of a murine pancreas using extended-focus Optical Cohere ...

2012

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

Chiara Greggio

The pancreas plays a central role in metabolism. The exocrine pancreas, composed of ductal and acinar cells, secretes and delivers digestive enzymes into the duodenum where they contribute to food digestion. The endocrine pancreas, constituted by the islet ...

EPFL2011

Neurogenin3 Initiates Stepwise Delamination of Differentiating Endocrine Cells During Pancreas Development

Anne Grapin-Botton, Mathieu Gouzi, Yung Hae Kim, Keiichi Katsumoto

During development, pancreatic endocrine cells are specified within the pancreatic epithelium. They subsequently delaminate out of the epithelium and cluster in the mesenchyme to form the islets of Langerhans. Neurogenin3 (Ngn3) is a transcription factor r ...

2011

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

Role of Neurogenin3 in migration of pancreatic endocrine cells during development

Mathieu Gouzi

The pancreas is one of the major organs of the digestive tract. Its endocrine function, mainly regulating glucose blood level, is achieved by endocrine cells. These cells are organized in clusters, the so-called islets of Langerhans. During development, th ...

EPFL2010

Wnt Signaling in Pancreas Development and Cancer

During early somite stages of development, the broad endoderm-derived foregut and hindgut territories become further subdivided along the antero-posterior axis into organs. One of these organs is the pancreas which serves two major physiological functions: ...

EPFL2010

Pancreas

Graph Chatbot

Chat with Graph Search

Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis

Planar Cell Polarity Controls Pancreatic Endocrine Differentiation

Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival

GLUT2-/- mice are resistant to age-induced accumulation of fat in the liver – an in vivo MRS study

Diabetes imaging — quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

Neurogenin3 Initiates Stepwise Delamination of Differentiating Endocrine Cells During Pancreas Development

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Role of Neurogenin3 in migration of pancreatic endocrine cells during development

Wnt Signaling in Pancreas Development and Cancer

Planar Cell Polarity Controls Pancreatic Endocrine Differentiation

Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis

Role of Neurogenin3 in migration of pancreatic endocrine cells during development

Diabetes imaging — quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy

GLUT2-/- mice are resistant to age-induced accumulation of fat in the liver – an in vivo MRS study

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

Neurogenin3 Initiates Stepwise Delamination of Differentiating Endocrine Cells During Pancreas Development

Wnt Signaling in Pancreas Development and Cancer