Concept
Corneal dystrophy
Related publications (17)
Corneal epithelial stem cells and their niche at a glance
The corneal epitheliumacts as a protective barrier on the anterior ocular surface and is essential for maintaining transparency of the cornea and thus visual acuity. During both homeostasis and repair, the corneal epithelium is maintained by self-renewing ...
Company Of Biologists Ltd2017Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction
Freddy Radtke, Matthias Lütolf, Georg Fantner, Yann Barrandon, Sylke Höhnel, Pascal Damian Odermatt, Craig Nowell, Luca Azzolin
Chronic inflammation is associated with a variety of pathological conditions in epithelial tissues, including cancer, metaplasia and aberrant wound healing. In relation to this, a significant body of evidence suggests that aberration of epithelial stem and ...
Nature Publishing Group2016Mechanical and Functional Study of Cell Physiology at the Nanoscale
By live-cell imaging of biological samples dynamic cellular processes can be resolved. Fluorescence microscopy (FM) and atomic force microscopy (AFM) are both capable of imaging live cells. By combining these techniques structural as well as functional inf ...
EPFL2016Enrichment of pathogenic alleles in the brittle cornea gene, ZNF469, in keratoconus
Keratoconus, a common inherited ocular disorder resulting in progressive corneal thinning, is the leading indication for corneal transplantation in the developed world. Genome-wide association studies have identified common SNPs 100 kb upstream of ZNF469 s ...
Oxford University Press2014Innovative strategy of corneal epithelium regeneration using fabricated soft contact lens containing cavities for stem cells transplantation
Transplantation of donor cornea is widely performed with a high success rate to treat patients with impaired corneal transparency. However the limited number of donors has led scientists to search for new technologies and treatments, including stem cell th ...
EPFL2014Corneal Endothelial Cell Fate Is Maintained by LGR5 Through the Regulation of Hedgehog and Wnt Pathway
Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), a target of Wnt signaling, is reportedly a marker of intestine, stomach, and hair follicle stem cells in mice. To gain a novel insight into the role of LGR5 in human corneal tissue, we per ...
Wiley-Blackwell2013Sutureless ocular surface reconstruction
Corneal diseases account for eight million blind people worldwide, making up to 10% of all causes of blindness. As 80% of the information is collected by our senses, blindness is a very invalidating condition which lowers greatly patients’ quality of life. ...
2010Essential Role for Pbx1 in Corneal Morphogenesis
PURPOSE. The Pbx TALE (three-amino-acid loop extension) homeodomain proteins interact with class 1 Hox proteins, which are master regulators of cell fate decisions. This study was performed to elucidate the role of the Pbx1 TALE protein in the corneal epit ...
2010Second harmonic generating (SHG) Nanoprobes: A new tool for biomedical imaging
Cornea functions as an outermost lens and plays an important role in vision. For cornea diagnosis and treatment, a microscopic imaging system with cellular resolution and high eye safety is strongly desired. Recently, the cell morphology of corneal epithel ...
2009Modeling the cornea: an architectural approach
Nowadays the mechanism regulating the corneal epithelium renewal still remains unclear. Until now it was thought to be the fact of stem cells distributed in the limbus, generating TA cells migrating towards the central cornea and responsible for its renewa ...
2009