Concept

Human serum albumin

Related publications (64)

Bicyclization and tethering to albumin yields long-acting Peptide antagonists

Christian Heinis, Alessandro Angelini, Shiyu Chen, Philippe Diderich, Julia Morales Sanfrutos

Proteolytically stable peptide architectures are required for the development of long-acting peptide therapeutics. In this work, we found that a phage-selected bicyclic peptide antagonist exhibits an unusually high stability in vivo and subsequently deciph ...

Amer Chemical Soc2012

Immunosuppressive Activity of Size-Controlled PEG-PLGA Nanoparticles Containing Encapsulated Cyclosporine A

Li Tang

We encapsulated cyclosporine A (CsA) in poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (PEG-PLGA) nanoparticles (NPs) by nanoprecipitation of CsA and PEG-PLGA. The resulting CsA/PEG-PLGA-NPs were

2012

Chemical functionalization of bio-ceramics to enhance endothelial cells adhesion for tissue engineering

Sandrine Gerber, Françoise Borcard

To control the selective adhesion of human endothelial cells and human serum proteins to bioceramics of different compositions, a multifunctional ligand containing a cyclic arginine-glycine-aspartate (RGD) peptide, a tetraethylene glycol spacer, and a gall ...

American Chemical Society2012

Squaric Acid Mediated Chemoselective PEGylation of Proteins: Reactivity of Single-Step-Activated alpha-Amino Poly(ethylene glycol)s

Harm-Anton Klok, Frederik Roman Wurm

The covalent attachment of poly(ethylene glycol) (PEG) to therapeutically active proteins (PEGylation) has become an important method to deal with the pharmacological difficulties of these polypeptides, such as short body-residence times and immunogenicity ...

Wiley-V C H Verlag Gmbh2012

Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

Giovanni Dietler, Hilal Lashuel, Francesco Simone Ruggeri, Jae Sun Jeong, Raffaele Mezzenga

We report the investigation of the mechanical properties of different types of amyloid fibrils by the peak force quantitative nanomechanical (PF-QNM) technique. We demonstrate that this technique correctly measures the Young's modulus independent of the po ...

2012

X-ray absorption spectroscopy studies of the adducts formed between cytotoxic gold compounds and two major serum proteins

Angela Casini

Gold metallodrugs form a class of promising antiproliferative agents showing a high propensity to react with proteins. We exploit here X-ray absorption spectroscopy (XAS) methods [both X-ray absorption near-edge spectroscopy (XANES) and extended X-ray abso ...

Springer Verlag2011

Human serum albumin binding and cytotoxicity studies of surfactant–cobalt(III) complex containing 1,10-phenanthroline ligand

Hubert van den Bergh, Georges Wagnières

The characteristics of the binding reaction of surfactant-cobalt(III) complex, cis-[Co(phen)(2)(C14H29NH2)]Cl-2 center dot 3H(2)O (phen =1,10-phenanthroline, C14H29NH2 = tetradecylamine) with human serum albumin (HSA) were studied by fluorescence and UV-vi ...

Elsevier2011

Effect of the environment on wear ranking and corrosion of biomedical CoCrMo alloys

Stefano Mischler

The corrosion behaviour and the wear ranking of biomedical high carbon (HC) and low carbon (LC) CoCrMo alloys sliding against an alumina ball in four different simulated body fluids [NaCl and phosphate buffered solutions (PBS) with and without albumin] has ...

2011

Multi-panel drugs detection in human serum for personalized therapy

Giovanni De Micheli, Sandro Carrara, Andrea Cavallini

This work focuses on P450 biosensors based on multiwalled carbon nanotubes (MWCNT) and different cytochrome isoforms: 3A4, 2B4, 2C9. The proposed biosensors exhibit enhanced sensitivities and decreased detection limits thanks to carbon nanotubes. The MWCNT ...

Elsevier2011

Fretting-corrosion behavior of beta titanium alloys in simulated synovial fluid

Stefano Mischler

Fretting-corrosion is a material degradation process resulting from the combined action of a corrosive environment and small displacement fretting wear. In this work, the fretting-corrosion behavior of Ti-12.5Mo, Ti-13Nb-13Zr, and Ti-29Nb-13Ta-4.6Zr, beta ...

2011

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