Concept

Fumarase

Related publications (4)

Mitochondrial unfolded protein response, its molecular mechanism and physiological impact

Mitochondria are the main producers of ATP, the energy currency of the cell, and they perform a wide array of other fundamental functions. These organelles are essential not only for cellular metabolism, but also for organismal physiology and lifespan. A r ...

EPFL2016

In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance

Rolf Gruetter, Mor-Miri Mishkovsky, Arnaud Comment

The Krebs (or tricarboxylic acid (TCA)) cycle has a central role in the regulation of brain energy regulation and metabolism, yet brain TCA cycle intermediates have never been directly detected in vivo. This study reports the first direct in vivo observati ...

Nature Publishing Group2012

Production of a thermostable fumarase in Saccharomyces cerevisiae for the bioconversion of fumarate to L-malate

Coralie Signorell

The gene encoding fumarase (fum) from Thermus thermophilus was expressed in yeast Saccharomyces cerevisiae. The recombinant cells were heated at 70°C to inactivate indigenous enzymes and used for the bioconversion of fumaric acid to L-malic acid. By heatin ...

2011

The role of contact sites between inner and outer mitochondrial membrane in energy transfer

Rudolf Hovius

Three functions have been suggested to be localized in contact sites between the inner and the outer membrane of mitochondria from mammalian cells: (i) transfer of energy from matrix to cytosol through the action of peripheral kinases; (ii) import of mitoc ...

1990

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