Concept
Multiple sequence alignment
Related publications (225)
TTool: A Supervised Artificial Intelligence-Assisted Visual Pose Detector for Tool Heads in Augmented Reality Woodworking
Yves Weinand, Julien Gamerro, Andrea Settimi, Florian Aymanns, Naravich Chutisilp
We present TimberTool (TTool v2.1.1), a software designed for woodworking tasks assisted by augmented reality (AR), emphasizing its essential function of the real-time localization of a tool head’s poses within camera frames. The localization process, a fu ...
2024Safe Deep Neural Networks
The capabilities of deep learning systems have advanced much faster than our ability to understand them. Whilst the gains from deep neural networks (DNNs) are significant, they are accompanied by a growing risk and gravity of a bad outcome. This is tr ...
Generative power of a protein language model trained on multiple sequence alignments
Anne-Florence Raphaëlle Bitbol, Damiano Sgarbossa, Umberto Lupo
Computational models starting from large ensembles of evolutionarily related protein sequences capture a representation of protein families and learn constraints associated to protein structure and function. They thus open the possibility for generating no ...
eLIFE SCIENCES PUBL LTD2023Combining phylogeny and coevolution improves the inference of interaction partners among paralogous proteins
Anne-Florence Raphaëlle Bitbol
Author summaryWhen two protein families interact, their sequences feature statistical dependencies. First, interacting proteins tend to share a common evolutionary history. Second, maintaining structure and interactions through the course of evolution yiel ...
PUBLIC LIBRARY SCIENCE2023Impact of phylogeny on structural contact inference from protein sequence data
Anne-Florence Raphaëlle Bitbol, Nicola Dietler, Umberto Lupo
Local and global inference methods have been developed to infer structural contacts from multiple sequence alignments of homologous proteins. They rely on correlations in amino acid usage at contacting sites. Because homologous proteins share a common ance ...
ROYAL SOC2023Smart filter aided domain adversarial neural network for fault diagnosis in noisy industrial scenarios
Olga Fink, Gaëtan Michel Frusque, Tianfu Li, Qi Li, Baorui Dai
The application of unsupervised domain adaptation (UDA)-based fault diagnosis methods has shown significant efficacy in industrial settings, facilitating the transfer of operational experience and fault signatures between different operating conditions, di ...
2023Species-specific regulation of XIST by the JPX/FTX orthologs
X chromosome inactivation (XCI) is an essential process, yet it initiates with remarkable diversity in various mammalian species. XIST, the main trigger of XCI, is controlled in the mouse by an interplay of lncRNA genes (LRGs), some of which evolved concom ...
OXFORD UNIV PRESS2023Learnable Wavelet Transform and Domain Adversarial Learning for Enhanced Bearing Fault Diagnosis
Olga Fink, Gaëtan Michel Frusque, Qi Li, Baorui Dai
The application of unsupervised domain adaptation (UDA)-based fault diagnosis methods has shown significant efficacy in industrial settings, facilitating the transfer of operational experience and fault signatures between different operating conditions, di ...
Research Publishing2023Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework
Andrea Pfeifer, Florence Gauye, Tariq Afroz, Monisha Ratnam
Optimal pharmacokinetic (PK) properties of therapeutic monoclonal antibodies (mAbs) are essential to achieve the desired pharmacological benefits in patients. To accomplish this, we followed an approach comprising structure-based mAb charge engineering in ...
TAYLOR & FRANCIS INC2023Network Alignment With Holistic Embeddings
Thanh Trung Huynh, Quoc Viet Hung Nguyen, Thành Tâm Nguyên, Chi Thang Duong
Network alignment is the task of identifying topologically and semantically similar nodes across (two) different networks. It plays an important role in various applications ranging from social network analysis to bioinformatic network interactions. Howeve ...
IEEE COMPUTER SOC2023