Concept

Flux balance analysis

Related publications (103)

Metabolic networks: enzyme function and metabolite structure

A review and discussion. Metab. is one of the most complex cellular processes. Connections between biochem. reactions via substrate and product metabolites create complex metabolic networks that may be analyzed using network theory, stoichiometric anal., a ...

2004

Computational discovery of biochemical routes to specialty chemicals

Vassily Hatzimanikatis

A computational framework has been developed for the construction and evaluation of metabolic pathways given input substrates and knowledge of enzyme-catalyzed reactions. Application of the framework creates new and existing routes to both chems. known to ...

2004

Quantitative comparison of transient growth of Saccharomyces cerevisiae, Saccharomyces kluyveri, and Kluyveromyces lactis

Urs von Stockar, Christoph Herwig

A multitude of metabolic regulations occur in yeast, particularly under dynamic process conditions, such as under sudden glucose excess. However, quantification of regulations and classification of yeast strains under these conditions have yet to be elucid ...

2003

Quantification and characterization of uncertainty in metabolic engineering

Vassily Hatzimanikatis

One of the central problems in metabolic engineering deals with the identification of the "rate limiting steps", i.e. enzymes whose activities one should manipulate towards the achievement of a desirable performance. However, uncertainty about the kinetic ...

2003

Chemically resolved imaging of biological cells and thin films by infrared scanning near-field optical microscopy

Giorgio Margaritondo

The infrared (IR) absorption of a biological system can potentially report on fundamentally important microchemical properties. For example, molecular IR profiles are known to change during increases in metabolic flux, protein phosphorylation, or proteolyt ...

2003

A small metabolic flux model to identify transient metabolic regulations in Saccharomyces cerevisiae

Urs von Stockar, Christoph Herwig

The understanding of dynamic metabolic regulations is important for physiol. studies and strain characterization tasks. The present study combined transient expts. with online metabolic flux anal. (MFA) in order to quantify metabolic regulations, namely ca ...

2002

Heat flux as an on-line indicator of metabolic activity in pilot scale bioreactor during the production of Bacillus thuringiensis var. galleriae-based biopesticides

Urs von Stockar, Ian William Marison

The effective biotechnol. process development depends on the system for monitoring the activity of the culture during cultivation. The feasibility of monitoring the metabolic flux during the cultivation of Bacillus thuringiensis var. galleriae (Btg) in pil ...

2002

Feeding active neurons: (re)emergence of a nursing role for astrocytes

Pierre Magistretti, Luc Pellerin

Despite unquestionable evidence that glucose is the major energy substrate for the brain, data collected over several decades with different approaches suggest that lactate may represent a supplementary metabolic substrate for neurons. Starting with the pi ...

2002

Astaxanthin production by Phaffia rhodozyma

Urs von Stockar, Ian William Marison, Christopher Cannizzaro

Astaxanthin is primarily used as a food supplement in the aquaculture industry, which over the past twenty years has experienced tremendous growth. A complex synthetic process produces almost all of the astaxanthin sold, and consequently, the selling price ...

2000

Thermodynamic analysis of growth of Methanobacterium thermoautotrophicum

Urs von Stockar

Growth of Methanobacterium thermoautotrophicum, an anaerobic archaebacterium using methanogenesis as the catabolic pathway, is characterized by large heat prodn. rates, up to 13 W g-1, and low biomass yields, in the order of 0.02 C-mol mol-1 H2 consumed. T ...

1999

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