Publications related to Mitochondrial permeability transition pore

Multitarget-Directed Gallium(III) Tris(acyl-pyrazolonate) Complexes Induce Ferroptosis in Cancer Cells via Dysregulation of Cell Redox Homeostasis and Inhibition of the Mevalonate Pathway

Farzaneh Fadaei Tirani

A series of Ga(Q(n))(3) coordination compounds have been synthesized, where HQ(n) is 1-phenyl-3-methyl-4-RC(=O)-pyrazolo-5-one. The complexes have been characterized through analytical data, NMR and IR spectroscopy, ESI mass spectrometry, elemental analysi ...

AMER CHEMICAL SOC2023

Stimulation and homogenization of the protoporphyrin IX endogenous production by photobiomodulation to increase the potency of photodynamic therapy

Georges Wagnières, Jaroslava Joniová, Emmanuel Louis Arthur Gerelli, Cyrus Kazemiraad

Protoporphyrin IX (PpIX) is produced in the mitochondria and used as fluorescent contrast agent or photosensitizer after exogenous 5-aminolevulinic acid (ALA) delivery in cancer photodynamic detection and therapy (PDT). Although routinely used in the clini ...

ELSEVIER SCIENCE SA2021

Investigation of cell death mechanisms in human lymphatic endothelial cells undergoing photodynamic therapy

Witold Waldemar Kilarski

Background: Photodynamic therapy (PDT) has been shown to induce ablation and functional occlusion of tumor-associated lymphatic vessels. However, direct effects of PDT on lymphatic endothelial cells (LECs) have not been studied so far. The aim of this stud ...

Elsevier Science Bv2016

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

Yi Zhang, Friedrich Beermann, Jie Zhang, Yuan Liu, Qian Zhang, Li Li, Ang Li, Ping Chen, Bo Zhou, Rong Wu

Autophagy is linked to cell death, yet the associated mechanisms are largely undercharacterized. We discovered that melanoma, which is generally resistant to drug-induced apoptosis, can undergo autophagic cell death with the participation of orphan nuclear ...

Nature Publishing Group2014

The anti-lymphoma activity of APO866, an inhibitor of nicotinamide adenine dinucleotide biosynthesis, is potentialized when used in combination with anti-CD20 antibody

Pierre Vogel, Somi Reddy Majjigapu, Bernard Sordat

APO866 is an inhibitor of nicotinamide adenine dinucleotide (NAD) biosynthesis that exhibits potent anti-lymphoma activity. Rituximab (RTX), an anti-CD20 antibody, kills lymphoma cells by direct apoptosis and antibody- and complement-dependent cell-mediate ...

Informa Healthcare2014

Conditional Deletion of Ferritin H in Mice Reduces B and T Lymphocyte Populations

Liviu Vanoaica, Maike Jaworski

The immune system and iron availability are intimately linked as appropriate iron supply is needed for cell proliferation, while excess iron, as observed in hemochromatosis, may reduce subsets of lymphocytes. We have tested the effects of a ferritin H gene ...

Public Library of Science2014

Comparative Study on the In Vitro Cytotoxicity of Linear, Dendritic, and Hyperbranched Polylysine Analogues

Harm-Anton Klok, Florian Maria Wurm, David Hacker, Lucia Baldi Unser, Zuzana Kadlecova

Lysine-based polycations are widely used as nonviral carriers for gene delivery. This manuscript reports the results of a comparative study on the in vitro cytotoxicity of a library of three structural polylysine variants, namely, linear polylysine (LPL), ...

Amer Chemical Soc2012

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

Liliane Glauser, Darren Moore, Klodjan Stafa, Ying Liu, David Ramonet Jimenez

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemical fe ...

Public Library of Science2011

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Mitochondrial permeability transition pore

Multitarget-Directed Gallium(III) Tris(acyl-pyrazolonate) Complexes Induce Ferroptosis in Cancer Cells via Dysregulation of Cell Redox Homeostasis and Inhibition of the Mevalonate Pathway

Stimulation and homogenization of the protoporphyrin IX endogenous production by photobiomodulation to increase the potency of photodynamic therapy

Investigation of cell death mechanisms in human lymphatic endothelial cells undergoing photodynamic therapy

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

The anti-lymphoma activity of APO866, an inhibitor of nicotinamide adenine dinucleotide biosynthesis, is potentialized when used in combination with anti-CD20 antibody

Conditional Deletion of Ferritin H in Mice Reduces B and T Lymphocyte Populations

Comparative Study on the In Vitro Cytotoxicity of Linear, Dendritic, and Hyperbranched Polylysine Analogues

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

Gene Delivery with Hyperbranched Polylysine

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Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

Stimulation and homogenization of the protoporphyrin IX endogenous production by photobiomodulation to increase the potency of photodynamic therapy

Multitarget-Directed Gallium(III) Tris(acyl-pyrazolonate) Complexes Induce Ferroptosis in Cancer Cells via Dysregulation of Cell Redox Homeostasis and Inhibition of the Mevalonate Pathway

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

The anti-lymphoma activity of APO866, an inhibitor of nicotinamide adenine dinucleotide biosynthesis, is potentialized when used in combination with anti-CD20 antibody

Comparative Study on the In Vitro Cytotoxicity of Linear, Dendritic, and Hyperbranched Polylysine Analogues

Investigation of cell death mechanisms in human lymphatic endothelial cells undergoing photodynamic therapy

Conditional Deletion of Ferritin H in Mice Reduces B and T Lymphocyte Populations

Gene Delivery with Hyperbranched Polylysine