Concept

Linezolid

Related publications (4)

In Vitro and In Vivo Activities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis

Stewart Cole, Neeraj Dhar, Claudia Sala, Anthony Vocat, Ming Zhang

Oxazolidinones represent a new class of antituberculosis drugs that exert their function by inhibiting protein synthesis. Here, we compared the activities of three oxazolidinones, linezolid, PNU-100480, and AZD5847, against latent tuberculosis using a simp ...

Amer Soc Microbiology2014

Chemo- and stereoselective glycosylation of hydroxylamino derivatives: A versatile approach to glycoconjugates

A general method for the stereoselective coupling of unprotected oligosaccharides with any substrate containing a N,O-disubstituted hydroxylamine group is described. The cyclic nature of the oligosaccharide reducing unit is preserved and the substrate glyc ...

1998

Formation and characterization of lipopeptide layers at interfaces for the molecular recognition of antibodies

Horst Vogel, Claus Duschl

A lipopeptide, carrying the antigenic peptide segment 135-154 of VP1, one of the capsid proteins of the picornavirus which causes foot-and-mouth disease in cattle, was investigated in lipid monolayers on the water surface and on hydrophobic solid supports. ...

1996

The first examples of SNAr-based macrocyclization: synthesis of model carboxylate-binding pockets of vancomycin

Jieping Zhu

Model carboxylate-binding pocket C-O-D rings of vancomycin and related glycopeptides were efficiently synthesized by intramol. SNAr reactions. Thus, treatment of precursors I (R = H, 4-HOC6H4) with K2CO3 in DMF gave cyclic diaryl ethers II (R1 = NO2), with ...

1994

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