Critical theory | EPFL Graph Search

A critical theory is any approach to social philosophy that focuses on society and culture to attempt to reveal, critique, and challenge power structures. With roots in sociology and literary criticism, it argues that social problems stem more from social structures and cultural assumptions than from individuals. It argues that ideology is the principal obstacle to human liberation. Critical theory finds applications in various fields of study, including psychoanalysis, sociology, history, communication theory, philosophy and feminist theory. Critical Theory (capitalized) is a school of thought practiced by the Frankfurt School theoreticians Herbert Marcuse, Theodor Adorno, Walter Benjamin, Erich Fromm, and Max Horkheimer on the one hand, and on the other any philosophical approach that seeks to liberate people from all forms of oppression and actively works to create a world in accordance with human needs (usually called "critical theory", without capitalization). Philosophical appr

Preventing Breaks in Embodiment in Immersive Virtual Reality

Thibault Serge Mario Porssut

Virtual reality (VR) is immersive not only because of visual integration, but because we can act and perform in a virtual environment (VE). Beyond the mere fact that a VR system provides images computed directly from the users' viewpoint in stereoscopy, it can also provide a natural way to interact within the VE using the entire body. Full-body motion capture allows the user's movement to be mapped to a virtual body. Such a mapping may let users feel in control of (sense of agency), own (sense of body ownership) and locate themselves inside this virtual body (sense of self-location), thus leading them to feel embodied in this virtual body whenever these conditions are met (sense of embodiment (SoE)). Hence the integration of a full body avatar in VR is essential, as it brings even more; experiencing being someone else, train to recover mobility or having superhuman abilities. Most importantly, the avatar mediates the virtual nature of the VE to make it seamless for the user. Thus, this thesis focuses on helping the users execute complex movements in VR by applying a distortion to their movements. However, such a distortion is efficient only if users, when assisted, do not experience a break in embodiment (BiE), i.e., do not abruptly lose their sense of embodiment. Moreover, the way the virtual body is perceived is not consistent between users and some users might accept or reject a virtual body more easily than others. Therefore, this thesis explores how to prevent a BiE while distorting users' movement and adapting the VR experience to each individual. To this end, we designed a system combining brain-computer interface and machine learning to detect when users experience a BiE, compute users' preferences, and adapt the VR application's parameters. We first identified the user`s threshold for perceiving a movement distortion in some critical contexts, such as articular limits. We designed a new distortion to help users execute a complex movement. We introduced a method based on machine learning to find users' preferences when using our new distortion. We also established a link between the brain's error monitoring mechanism and the cognitive process of embodiment. This link exposed a new implicit EEG marker indicating when users experience a BiE. Finally, we designed a system to calibrate the distortion implicitly based on users' preferences with all these elements. This system first consists of detecting a BiE during a continuous movement thanks to state-of-the-art brain-computer interface algorithms. Our machine learning method then computes users' preferences, and the distortion is adapted dynamically. This original approach demonstrates the use of an implicit feedback loop to help users while preventing any BiE. Our framework opens an exciting perspective for personalized and self-adapting embodiment systems.

EPFL2021

Identification and characterisation of small-molecule inhibitors targeting STING

Simone Margret Haag

The recognition of pathogen-derived nucleic acids is a critical mechanism by which the innate immune system detects viral infection. Upon activation, nucleic acid sensors initiate the expression of type I interferons and other inflammatory mediators, subsequently leading to potent antiviral immune responses. However, erroneous detection of nucleic acids can have deleterious consequences for the host by inducing the development of certain autoinflammatory disorders. Inappropriate sensing of self- nucleic acids underlies a spectrum of monogenic disease referred to as type interferonopathies, including the Aicardi-Goutières syndrome (AGS). These disorders are often driven by mutations in genes encoding for components of nucleic acid recognition pathways, thereby resulting in the constitutive activation of type I interferon responses. Insight into the molecular pathology of AGS has highlighted promising new targets that may be harnessed for the development of novel therapeutics to counter this disorder. Stimulator of interferon genes (STING) - a central adaptor of the cytosolic DNA sensing pathway - has been strongly implicated in the pathogenesis of distinct inflammatory disorders, including AGS. Therefore, pharmacological inhibition of STING presents a promising approach for the development of potent treatment strategies against these and potentially other STING-mediated, autoinflammatory diseases. Performing a cell-based small-molecule screen, we identified and characterized two series of compounds, which potently and selectively inhibit STING through a mechanism that blocks the activation-induced palmitoylation of STING. The identified small-molecules mediate this inhibition through covalent binding to a transmembrane predicted cysteine residue (Cys91) - a palmitoylation site required for STING activation. Using the inhibitors, we show that the palmitoylation of STING mediates the formation of multimeric complexes at the Golgi and the subsequent recruitment and activation of the direct downstream kinase TBK1. We also provide evidence that representatives of both identified compound classes potently inhibit STING-induced expression of inflammatory cytokines including type I interferon, in human and mouse cells. Furthermore, we also demonstrate that the identified STING inhibitors attenuate autoinflammatory disease features in a mouse model of AGS. Taken together, this work uncovers a small-molecule mediated mechanism to inhibit STING and demonstrates the pharmacological potential of targeting STING for the treatment of type I interferon driven disease such as AGS.

EPFL2019

A Third Way Alternative; Critical Assessments from the Model of the Yugoslav City

Jana Konstantinova

This dissertation aims to demonstrate the development, meaning and significance of cultural infrastructure in the cities of Skopje, Belgrade and Sarajevo (1945-1991). In the historic context, culture became the fundamental critical tool with which to yield a vivid cultural scene, and it coincides with the emergence of remarkable cultural artefacts - including 'the right architecture'. The thesis recognizes a common (Yugoslav) Creative Model behind this âmovementâ, which stimulated and anticipated the emergence of the elements that eventually form the cultural artefacts. For the purpose of studying the strengths and weaknesses of the model, the exercise investigates the extensive body of cultural creations which emerged through the model. As such, the thesis highlights the flow of creativity, and the particular understanding of creativity as a âlife qualityâ in support of the theoretical concept of balance which emerged in the local context - striving for equilibrium between the man-made, the human (civic) and the natural environment. The aims of the research are threefold. Firstly, to understand the objectives on which the model is created; secondly, to reposition the object â cultural artefact â as a departure point of analysis of the model; and thirdly, to analyze the evolution of the cultural infrastructure in the environments to trace the transformations of the model. To that end an analysis of the entire cultural creation of the epoch has been carried out in relation with the specific interest of the thesis. The exercises are conducted by drawing from the primary data sets (the press: both architectural and cultural magazines) and the secondary sets of data (original documents and testimonials with the protagonists: wider cultural milieu). Bridging the epistemological gap in the academic discourse, exemplifying the selected cities not as isolated case studies but in comparative synthesis, the thesis positions these rich cultural, spatial and social qualities (collected in the form of a critical archive) and their common Creative Model as the possibility to depart from the neo-liberal paradigm still affecting regions globally and to re-imagine our own current models for human settlements in ways more open to people, nature and culture.

EPFL2021

Identification and characterisation of small-molecule inhibitors targeting STING

Simone Margret Haag

EPFL2019

A Third Way Alternative; Critical Assessments from the Model of the Yugoslav City

Jana Konstantinova

EPFL2021

Preventing Breaks in Embodiment in Immersive Virtual Reality

Thibault Serge Mario Porssut

EPFL2021