Publications related to Alcohol (drug)

Structural studies of Mycobacterium tuberculosis DprE1 interacting with its inhabitors

Stewart Cole, Jérémie Piton, Shi-Yan Caroline Foo

The flavoenzyme DprEl catalyses a crucial step in arabinan production for cell wall biosynthesis in Mycobacterium tuberculosis and is a highly vulnerable drug target. It was first discovered using benzothiazinones (BTZ): exquisitely potent bactericidal age ...

Elsevier Sci Ltd2017

Alcohol-Induced C-N Bond Cleavage of Cyclometalated N-Heterocyclic Carbene Ligands with a Methylene-Linked Pendant Imidazolium Ring

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Wei Zhong

Reaction of the pentamethylcyclopentadienyl rhodium iodide dimer Cp*RhI2 with 1,1'-diphenyl-3,3'-methylenediimidazolium diiodide in non-alcohol solvents, in the presence of base, led to the formation of bis-carbene complex [Cp*Rh(bis-NHC)I] I (bis-NHC ...

Wiley-Blackwell2016

Thermally-nucleated self-assembly of water and alcohol into stable structures at hydrophobic interfaces

Francesco Stellacci, Michele Ceriotti, Kislon Voitchovsky, Daniele Giofré

At the interface with solids, the mobility of liquid molecules tends to be reduced compared with bulk, often resulting in increased local order due to interactions with the surface of the solid. At room temperature, liquids such as water and methanol can f ...

Nature Publishing Group2016

Total Synthesis of Fijiolide A

Nicolai Cramer, Christoph Heinz

Fijiolide A is a secondary metabolite isolated from a marine-derived actinomycete of the genus Nocardiopsis. It was found to significantly reduce the TNF-alpha induced activity of the transcription factor NF kappa B, which is considered a promising target ...

Schweizerische Chemische Gesellschaft2016

Arene Osmium Complexes with Ethacrynic Acid-Modified Ligands: Synthesis, Characterization, and Evaluation of Intracellular Glutathione S-Transferase Inhibition and Antiproliferative Activity

Paul Joseph Dyson, Tina Riedel, Emilia Paunescu

Four arene osmium complexes were prepared containing derivatives of ethacrynic acid, a potent inhibitor of glutathione Stransferases, either by direct coordination or via N- or P-donor ligands. The complexes were characterized by spectroscopic and analytic ...

American Chemical Society2016

Aluminium Foil as Single-Use Substrate for MALDI-MS Fingerprinting of Different Melanoma Cell Lines

Hubert Girault, Horst Pick, Liang Qiao, Fernando Cortes Salazar, Yingdi Zhu, Alexandra Bondarenko

Herein, we present the intact cell matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) for the fingerprinting of human melanoma cancer cell lines grown on aluminium foil. To perform the MALDI-MS assay, melanoma cells were cultured on a ...

Royal Soc Chemistry2016

A streamlined search technology for identification of synergistic drug combinations

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska

A major key to improvement of cancer therapy is the combination of drugs. Mixing drugs that already exist on the market may offer an attractive alternative. Here we report on a new model-based streamlined feedback system control (s-FSC) method, based on a ...

Nature Publishing Group2015

Structural and functional connectivity in the default mode network in 22q11.2 deletion syndrome

Dimitri Nestor Alice Van De Ville, Maude Schneider, Marie Schaer, Maria Carmela Padula

Background: The neural endophenotype associated with 22q11.2 deletion syndrome (22q11DS) includes deviant cortical development and alterations in brain connectivity. Resting-state functional magnetic resonance imaging (fMRI) findings also reported disconne ...

BioMed Central2015

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Alcohol (drug)

Structural studies of Mycobacterium tuberculosis DprE1 interacting with its inhabitors

Alcohol-Induced C-N Bond Cleavage of Cyclometalated N-Heterocyclic Carbene Ligands with a Methylene-Linked Pendant Imidazolium Ring

Thermally-nucleated self-assembly of water and alcohol into stable structures at hydrophobic interfaces

Just One More: Modeling Binge Watching Behavior

Total Synthesis of Fijiolide A

Arene Osmium Complexes with Ethacrynic Acid-Modified Ligands: Synthesis, Characterization, and Evaluation of Intracellular Glutathione S-Transferase Inhibition and Antiproliferative Activity

Aluminium Foil as Single-Use Substrate for MALDI-MS Fingerprinting of Different Melanoma Cell Lines

Influence of the Sparger Type and Added Alcohol on the Gas Holdup of an External-Loop Airlift Reactor

A streamlined search technology for identification of synergistic drug combinations

Structural and functional connectivity in the default mode network in 22q11.2 deletion syndrome

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Structural studies of Mycobacterium tuberculosis DprE1 interacting with its inhabitors

Influence of the Sparger Type and Added Alcohol on the Gas Holdup of an External-Loop Airlift Reactor

Total Synthesis of Fijiolide A

Alcohol-Induced C-N Bond Cleavage of Cyclometalated N-Heterocyclic Carbene Ligands with a Methylene-Linked Pendant Imidazolium Ring

Thermally-nucleated self-assembly of water and alcohol into stable structures at hydrophobic interfaces

Arene Osmium Complexes with Ethacrynic Acid-Modified Ligands: Synthesis, Characterization, and Evaluation of Intracellular Glutathione S-Transferase Inhibition and Antiproliferative Activity

Aluminium Foil as Single-Use Substrate for MALDI-MS Fingerprinting of Different Melanoma Cell Lines

A streamlined search technology for identification of synergistic drug combinations

Structural and functional connectivity in the default mode network in 22q11.2 deletion syndrome

Just One More: Modeling Binge Watching Behavior