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Concept

Membrane estrogen receptor

Membrane estrogen receptors (mERs) are a group of receptors which bind estrogen. Unlike the estrogen receptor (ER), a nuclear receptor which mediates its effects via genomic mechanisms, mERs are cell surface receptors which rapidly alter cell signaling via modulation of intracellular signaling cascades. Putative mERs include membrane-associated ERα (mERα) and ERβ (mERβ), GPER (GPR30), GPRC6A, ER-X, ERx and Gq-mER. The mERs have been reviewed.

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