Concept

Telophase

Related publications (95)

Importin-beta modulates the permeability of the nuclear pore complex in a Ran-dependent manner

Soluble karyopherins of the importin-beta (imp beta) family use RanGTP to transport cargos directionally through the nuclear pore complex (NPC). Whether imp beta or RanGTP regulate the permeability of the NPC itself has been unknown. In this study, we iden ...

Elife Sciences Publications Ltd2015

Multivalency governs HP1α association dynamics with the silent chromatin state

Beat Fierz, Louise Catherine Bryan, Sinan Kilic, Andreas Linus Bachmann

Multivalent interactions between effector proteins and histone post-translational modifications are an elementary mechanism of dynamic chromatin signalling. Here we elucidate the mechanism how heterochromatin protein 1α (HP1α), a multivalent effector, is e ...

2015

NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane

Pierre Gönczy, Coralie Busso, Sachin Kotak

The positioning and the elongation of the mitotic spindle must be carefully regulated. In human cells, the evolutionary conserved proteins LGN/Gai1-3 anchor the coiled-coil protein NuMA and dynein to the cell cortex during metaphase, thus ensuring proper s ...

2014

Selective transport control on molecular velcro made from intrinsically disordered proteins

Sylvia Jeney

The selectivity and speed of many biological transport processes(1) transpire from a 'reduction of dimensionality'(2) that confines diffusion to one or two dimensions instead of three(3). This behaviour remains highly sought after on polymeric surfaces(4) ...

Nature Publishing Group2014

A 2D/3D image analysis system to track fluorescently labeled structures in rod-shaped cells: application to measure spindle pole asymmetry during mitosis

Michaël Unser, Daniel Sage, Viesturs Simanis, Daniel Andreas Schmitter, Anastasia Chasapi, Ioannis Xenarios

Background: The yeast Schizosaccharomyces pombe is frequently used as a model for studying the cell cycle. The cells are rod-shaped and divide by medial fission. The process of cell division, or cytokinesis, is controlled by a network of signaling proteins ...

Biomed Central Ltd2013

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

Pierre Gönczy, Coralie Busso, Sachin Kotak

Spindle positioning and spindle elongation are critical for proper cell division. In human cells, an evolutionary conserved ternary complex (NuMA/LGN/Gαi) anchors dynein at the cortex during metaphase, thus ensuring correct spindle positioning. Whether thi ...

Nature Publishing Group2013

Redox-Responsive, Core-Cross-Linked Micelles Capable of On-Demand, Concurrent Drug Release and Structure Disassembly

Li Tang

We developed camptothecin (CPT)-conjugated, core-cross-linked (CCL) micelles that are subject to redox-responsive cleavage of the built-in disulfide bonds, resulting in disruption of the micellar structure and rapid release of CPT. CCL micelles were prepar ...

American Chemical Society2013

Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway

Romain Hamelin, Marc Moniatte, Amit Sharma, Guillem Dayer

Background: Protein kinase CK2 is a pleiotropic serine/threonine protein kinase with hundreds of reported substrates, and plays an important role in a number of cellular processes. The cellular functions of Plasmodium falciparum CK2 (PfCK2) are unknown. Th ...

2012

The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos

Pierre Gönczy, Coralie Busso

Regulation of mitosis in time and space is critical for proper cell division. We conducted an RNA interference-based modifier screen to identify novel regulators of mitosis in Caenorhabditis elegans embryos. Of particular interest, this screen revealed tha ...

Amer Soc Cell Biology2012

Isolation and Characterisation of Regulators of the Septation Initiation Network Regulators in Fission Yeast

Anupama Goyal

The septation initiation network (SIN) in Schizosaccharomyces pombe regulates cytokinesis. Cdc7p encodes the first kinase in the core SIN pathway. In this study, I performed a genetic screen to identify novel regulators of the SIN pathway by isolating spon ...

EPFL2012

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