Concept

Actin

Related publications (186)

Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Béatrice Kunz, Mirko Bischofberger, Romain Fernand Pietro Groux

The anthrax toxin is a tripartite toxin, where the two enzymatic subunits require the third subunit, the protective antigen (PA), to interact with cells and be escorted to their cytoplasmic targets. PA binds to cells via one of two receptors, TEM8 and CMG2 ...

Public Library of Science2010

Oxidative Stress on Human Cells in the Presence of Nano-Sized Titanium Dioxide

Katarzyna Pierzchala

Nanosized TiO2 (nanoTiO2) is one of the most widely used nanomaterials, with applications ranging from paints, self-cleaning coatings, pharmaceuticals, to food and cosmetics. In spite of this massive use of nanoTiO2, its biological activity and toxicity re ...

EPFL2010

The cytotoxic styryl lactone goniothalamin is an inhibitor of nucleocytoplasmic transport

Karl Gademann, Jean-Yves Wach

An in vivo nuclear export assay (immunostaining of Rio2 in HeLa cells) demonstrated that (R)-goniothalamin is an inhibitor of nucleocytoplasmic transport above 500 nM, which was rationalized also by molecular modeling. The cytotoxic styryl lactone natural ...

2010

Regulation of myofibroblast activities: Calcium pulls some strings behind the scene

Boris Hinz, Lysianne Follonier Castella

Myofibroblast-induced remodeling of collagenous extracellular matrix is a key component of our body's strategy to rapidly and efficiently repair damaged tissues; thus myofibroblast activity is considered crucial in assuring the mechanical integrity of vita ...

Elsevier2010

Hypoxia Impairs Skin Myofibroblast Differentiation and Function

Boris Hinz, Giorgio Pietramaggiori

Ischemic wounds are characterized by oxygen levels lower than that of healthy skin ( hypoxia) and poor healing. To better understand the pathophysiology of impaired wound healing, we investigated how switching from high ( 21%) to low ( 2%) oxygen levels di ...

Nature Publishing Group2010

Digital holographic microscopy real-time monitoring of cytoarchitectural alterations during simulated microgravity

Christian Depeursinge, Christophe Pache, Jonas Kühn, Muhammed Fatih Toy, Jérôme Parent, Marcel Egli

Previous investigations on mammalian cells have shown that microgravity, either that experienced in space, or simulated on earth, causes severe cellular modifications that compromise tissue determination and function. The aim of this study is to investigat ...

2010

Procentriole assembly revealed by cryo-electron tomography

Paul Guichard

Centrosomes are cellular organelles that have a major role in the spatial organisation of the microtubule network. The centrosome is comprised of two centrioles that duplicate only once during the cell cycle, generating a procentriole from each mature cent ...

2010

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL

Freddy Radtke

The Notch pathway is frequently activated in T-cell acute lymphoblastic leukemias (T-ALLs). Of the Notch receptors, Notch1 is a recurrent target of gain-of-function mutations and Notch3 is expressed in all T-ALLs, but it is currently unclear how these rece ...

2010

Role of focal adhesions and mechanical stresses in the formation and progression of the lamellum interface

Actin network in the front part of a moving cell is organized into a lamellipodium and a lamellum. A distinct lamellipodium-lamellum interface is associated with focal adhesions and consists of a series of arclike segments linking neighboring focal adhesio ...

2009

Actin-myosin viscoelastic flow in the keratocyte lamellipod

Maxime Fred Maurice Fournier, Alex Mogilner

The lamellipod, the locomotory region of migratory cells, is shaped by the balance of protrusion and contraction. The latter is the result of myosin-generated centripetal flow of the viscoelastic actin network. Recently, quantitative flow data was obtained ...

2009

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