Concept

Phagocyte

Related publications (106)

Electrical activity in rat cortico-limbic structures after single or repeated administration of lipopolysaccharide or staphylococcal enterotoxin B

Immune-to-brain communication is essential for an individual to aptly respond to challenging internal and external environments. However, the specificity by which the central nervous system detects or 'senses' peripheral immune challenges is still poorly u ...

2010

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

Andrea Ablasser

The inflammasome pathway functions to regulate caspase-1 activation in response to a broad range of stimuli. Caspase-1 activation is required for the maturation of the pivotal pro-inflammatory cytokines of the pro-IL-1beta family. In addition, caspase-1 ac ...

2010

Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice

Nicola Harris

The innate immune response plays an essential role in the prevention of early viral dissemination. We used the lymphocytic choriomeningitis virus model system to analyze the role of tissue macrophages/Kupffer cells in this process. Our findings demonstrate ...

2010

Towards anti-virulence drugs targeting ESX-1 mediated pathogenesis of Mycobacterium tuberculosis

Stewart Cole, Florence Pojer, Jeffrey Chen, Benjamin Blasco

Mycobacterium tuberculosis (M. tb) the causative agent of tuberculosis (TB) causes 1.7 million deaths annually. According to the World Health Organization, in some areas of the world, 25% of TB cases are due to multi- or extensively drug resistant M. tb st ...

Elsevier2010

Genetic ablation of Drosophila phagocytes reveals their contribution to both development and resistance to bacterial infection

Bruno Lemaitre

Drosophila phagocytes participate in development and immune responses through their abilities to perform phagocytosis and/or secrete extra-cellular matrix components, antimicrobial peptides, clotting factors and signalling molecules. However, our knowledge ...

2009

A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships

Michele De Palma, Ferdinando Pucci, Daniela Biziato

We previously showed that Tie2-expressing monocytes (TEMs) have nonredundant proangiogenic activity in tumors. Here, we compared the gene expression profile of tumor-infiltrating TEMs with that of tumor-associated macrophages (TAMs), spleen-derived Gr1(+)C ...

2009

An agarose-based microfluidic platform with a gradient buffer for 3D chemotaxis studies

Melody Swartz, Ulrike Haessler, Mingming Wu

The current state-of-art in 3D microfluidic chemotaxis device (mu FCD) is limited by the inherent coupling of the fluid flow and chemical concentration gradients. Here, we present an agarose-based 3D mu FCD that decouples these two important parameters, in ...

Springer Verlag2009

Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration

Melody Swartz, Joseph Rutkowski, Sai Reddy

Lymphatic vessels are essential for lipid absorption and transport. Despite increasing numbers of observations linking lymphatic vessels and lipids, little research has been devoted to address how dysregulation of lipid balance in the blood, ie, dyslipidem ...

American Society for Investigative Pathology2009

Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function

Nicola Harris, Benjamin John Marsland

Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine, mainly expressed by epithelial cells, and key to the development of allergic responses. The well-documented involvement of TSLP in allergy has led to the conviction that TSLP promo ...

2009

Functionalization of polysulfide nanoparticles and their performance as circulating carriers

Jeffrey Alan Hubbell, Nicola Tirelli, Annemie Rehor

We here present an evaluation of the carrier performance of nanoparticles that are biofunctional, i.e. derivatized to provide a controlled biological activity, and environmentally responsive, since they respond to the presence of oxidants. In particular, w ...

2008

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