Concept

Phagocyte

Related publications (106)

Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb

Etienne Meylan, Pedro Romero, Martin Etzrodt

Monocytes serve as a central defense system against infection and injury but can also promote pathological inflammatory responses. Considering the evidence that monocytes exist in at least two subsets committed to divergent functions, we investigated wheth ...

Elsevier2012

Partners in crime: VEGF and IL-4 conscript tumour-promoting macrophages

Michele De Palma

Tumour-associated macrophages (TAMs) foster tumour progression by several mechanisms, including the promotion of angiogenesis, tissue remodelling, and immunosuppression. Such pro-tumoural activities are thought to be executed by TAM subtypes that harbour f ...

Wiley-Blackwell2012

Lineage- and stage-restricted lentiviral vectors for the gene therapy of chronic granulomatous disease

Didier Trono, Isabelle Barde, Sonia Verp, Sandra Eloise Kjeldsen

Insertional mutagenesis represents a serious adverse effect of gene therapy with integrating vectors. However, although uncontrolled activation of growth-promoting genes in stem cells can predictably lead to oncological processes, this is far less likely i ...

2011

Inflammasomes: current understanding and open questions

Andrea Ablasser

The innate immune system relies on its capability to detect invading microbes, tissue damage, or stress via evolutionarily conserved receptors. The nucleotide-binding domain leucine-rich repeat (NLR)-containing family of pattern recognition receptors inclu ...

2011

The interplay between macrophages and angiogenesis in development, tissue injury and regeneration

Michele De Palma, Daniela Biziato

During organ development and remodeling, macrophages support angiogenesis, not only by secreting proangiogenic growth factors and matrix-remodeling proteases, but also by physically interacting with the sprouting vasculature to assist the formation of comp ...

2011

Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19

Marco Pisano, Melody Swartz, Ulrike Haessler, Mingming Wu

Dendritic cell (DC) homing to the lymphatics and positioning within the lymph node is important for adaptive immunity, and is regulated by gradients of CCL19 and CCL21, ligands for CCR7. Despite the importance of DC chemotaxis, it is not well understood ho ...

2011

Cell encapsulation technology as a novel strategy for human anti-tumor immunotherapy

Vivianne Padrun, Nicolas Bouche

Granulocyte-macrophage colony-stimulating factor (GM-CSF) as an adjuvant in autologous cell-based anti-tumor immunotherapy has recently been approved for clinical application. To avoid the need for individualized processing of autologous cells, we develope ...

Nature Publishing Group2011

In vivo labelling of resting monocytes in the reticuloendothelial system with fluorescent iron oxide nanoparticles prior to injury reveals that they are mobilized to infarcted myocardium

Heinrich Hofmann, Jean-Noël Hyacinthe, Alke Fink

To evaluate the feasibility of loading resting monocytes/macrophages by intravenous (i.v.) injection of fluorescent iron oxide nanoparticles prior to injury and tracking of these cells in the very same animal to myocardial infarction (MI) by magnetic reson ...

Oxford University Press2010

Contrasting persistence strategies in Salmonella and Mycobacterium

John McKinney, Anna De Graff Tischler

Long-term survival of persistent bacterial pathogens in mammalian hosts critically depends on their ability to avoid elimination by innate and adaptive immune responses. The persistent human pathogens that cause typhoid fever and tuberculosis exemplify alt ...

2010

Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation

Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Iraklis Kourtis

Vaccines aiming to activate cytotoxic T cells require cross-presentation of exogenous antigen by antigen-presenting cells (APCs). We recently developed a synthetic nanoparticle vaccine platform that targets lymph node-resident dendritic cells (DCs), capabl ...

Elsevier2010

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