Concept
Gene knockdown
Related publications (25)
Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Mohamed Adbelalim Gadalla
Hemagglutinin (HA), a glycoprotein of Influenza A viruses and its proton channel M2 are site-specifically modified with fatty acids. Whereas two cysteines in the short cytoplasmic tail of HA contain only palmitate, stearate is exclusively attached to one c ...
PORTLAND PRESS LTD2020Computational design of anti-CRISPR proteins with improved inhibition potency
Bruno Emanuel Ferreira De Sousa Correia, Sandrine Madeleine Suzanne Georgeon, Zander Harteveld, Andreas Scheck, Wei Sun, Stéphane Rosset, Julius Valten Upmeier Zu Belzen, Yujia Wang
Anti-CRISPR (Acr) proteins are powerful tools to control CRISPR-Cas technologies. However, the available Acr repertoire is limited to naturally occurring variants. Here, we applied structure-based design on AcrIIC1, a broad-spectrum CRISPR-Cas9 inhibitor, ...
NATURE PUBLISHING GROUP2020