Concept

Organoid

Related publications (144)

Organoid tissue engineering

Matthias Lütolf, Nathalie Brandenberg, Yoji Tabata, Nikolche Gjorevski, Mikhail Nikolaev

The invention relates to methods for developing and maintaining organoids and the organoids produced thereby. ...

2018

Progress and potential in organoid research

Matthias Lütolf, Giuliana Rossi, Andrea Manfrin

Tissue and organ biology are very challenging to study in mammals, and progress can be hindered, particularly in humans, by sample accessibility and ethical concerns. However, advances in stem cell culture have made it possible to derive in vitro 3D tissue ...

2018

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

Denis Duboule, Matthias Lütolf, Anne-Catherine Cossy, Leonardo Beccari, Mehmet Ugur Girgin, Alfonso Martinez Arias

The emergence of multiple axes is an essential element in the establishment of the mammalian body plan. This process takes place shortly after implantation of the embryo within the uterus and relies on the activity of gene regulatory networks that coordina ...

NATURE PUBLISHING GROUP2018

Advanced technologies to control stem-cell based organogenesis

Nathalie Brandenberg

Organoids represent the first in vitro cell culture systems that closely resemble native tissues in terms of cellular composition, architecture and key aspects of physiology. Through the discovery of these cultures, researchers could demonstrate that stem ...

EPFL2017

The hope and the hype of organoid research

Matthias Lütolf, Alfonso Martinez Arias

The recent increase in organoid research has been met with great enthusiasm, as well as expectation, from the scientific community and the public alike. There is no doubt that this technology opens up a world of possibilities for scientific discovery in de ...

Company of Biologists2017

Three dimensional hydrogels for culturing organoids

Matthias Lütolf, Nikolche Gjorevski

The invention provides hydrogels and methods for three-dimensional (3D) culture of adult epithelial stem cells and uses thereof. ...

2017

Perovskite solar cells with CuSCN hole extraction layers yield stabilized efficiencies greater than 20%

Michael Graetzel, Shaik Mohammed Zakeeruddin, Mohammad Ibrahim Dar, Neha Arora, Norman Pellet

Perovskite solar cells (PSCs) with efficiencies greater than 20% have been realized only with expensive organic hole-transporting materials. We demonstrate PSCs that achieve stabilized efficiencies exceeding 20% with copper(I) thiocyanate (CuSCN) as the ho ...

American Association for the Advancement of Science2017

In vitro evaluation of gel-encapsulated adipose derived stem cells: Biochemical cues for in vivo peripheral nerve repair

Stéphanie Lacour

Adipose‐derived stem cells (ASC) are becoming one of the most exploited cells in peripheral nerve repair. They are fast‐growing and able to protect neurons from apoptosis; they can reduce postinjury latency and the risk of muscle atrophy. This study evalua ...

Wiley-Blackwell2017

Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue

Paloma Ordonez Moran

The most prevalent single-nucleotide substitution (SNS) found in cancers is a C-to-T substitution in the CpG motif. It has been proposed that many of these SNSs arise during organismal aging, prior to transformation of a normal cell into a precancerous/can ...

2017

A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila

Bruno Lemaitre, Jean Philippe Boquete, Zongzhao Zhai

The speed of stem cell differentiation has to be properly coupled with self-renewal, both under basal conditions for tissue maintenance and during regeneration for tissue repair. Using the Drosophila midgut model, we analyze at the cellular and molecular l ...

2017

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