Related publications (45)

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Xiaoxu Li

Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...
EPFL2023

Impact of population size on early adaptation in rugged fitness landscapes

Anne-Florence Raphaëlle Bitbol, Richard Marie Servajean

Owing to stochastic fluctuations arising from finite population size, known as genetic drift, the ability of a population to explore a rugged fitness landscape depends on its size. In the weak mutation regime, while the mean steady-state fitness increases ...
ROYAL SOC2023

Hyperdimensional computing for biosignal monitoring: Applications for epilepsy detection

Una Pale

Hyperdimensional (HD) computing is a novel approach to machine learning inspired by neuroscience, which uses vectors in a hyper-dimensional space to represent data and models. This approach has gained significant interest in recent years with applications ...
EPFL2023

A generic diffusion-based approach for 3D human pose prediction in the wild

Alexandre Massoud Alahi, Saeed Saadatnejad, Taylor Ferdinand Mordan

Predicting 3D human poses in real-world scenarios, also known as human pose forecasting, is inevitably subject to noisy inputs arising from inaccurate 3D pose estimations and occlusions. To address these challenges, we propose a diffusion-based approach th ...
IEEE2023

A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development

Didier Trono, Julien Paul André Pontis, Johan Jakobsson

The human forebrain has expanded in size and complexity compared to chimpanzees despite limited changes in protein-coding genes, suggesting that gene expression regulation is an important driver of brain evolution. Here, we identify a KRAB-ZFP transcriptio ...
2022

Inactivation mechanisms of influenza A virus within the micro-environment of expiratory bioaerosols

Athanasios Nenes, Tamar Kohn, Kalliopi Violaki, Ghislain Gilles Jean-Michel Motos, Aline Laetitia Schaub, Shannon Christa David, Walter Hugentobler

Approximately 400’000 deaths are associated with influenza virus every year. Whilst currently dwarfed by the COVID-19 pandemic, influenza continues to circulate within the human population since the first recorded 1918 pandemic over a century ago. During t ...
2022

Experimental Study on Bedload Transport and Bedforms: Behaviour and Interplay in Steep Turbulent Streams

Ivan Pascal

In mountain regions, steep streams play an important role in water and sediment connectivity. In these highly dynamic systems, water flow features, sediment fluxes and stream morphologies are tightly interlinked over a broad range of temporal and spatial s ...
EPFL2022

Long Term Motion Prediction Using Keyposes

Pascal Fua, Mathieu Salzmann, Wei Wang, Sena Kiciroglu

Long term human motion prediction is essential in safety-critical applications such as human-robot interaction and autonomous driving. In this paper we show that to achieve long term forecasting, predicting human pose at every time instant is unnecessary. ...
2022

Safety-compliant Generative Adversarial Networks for Human Trajectory Forecasting

Alexandre Massoud Alahi, Parth Ashit Kothari

Human trajectory forecasting in crowds presents the challenges of modelling social interactions and outputting collision-free multimodal distribution. Following the success of Social Generative Adversarial Networks (SGAN), recent works propose various GAN- ...
2022

A platform for experimental precision medicine: The extended BXD mouse family

Johan Auwerx, Evan Graehl Williams

The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely ...
CELL PRESS2021

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