Publications related to Hepatotoxicity

Integration of the role of climate in the spatial modeling of waterborne hepatitis E virus

Hepatitis E virus (HEV) is among the major causes of acute viral hepatitis worldwide. In developing countries, HEV infections are caused by genotypes 1 and 2, due to consumption of contaminated water. Large and recurrent outbreaks of HEV occur in specific ...

2017

Modeling the present and future distribution of waterborne Hepatitis E virus

Stéphane Joost, Anna Carratala Ripolles

Hepatitis E is among the major causes of acute viral hepatitis worldwide. Infections occurring in industrialized countries are caused by zoonotic genotypes 3 and 4, mostly due to the consumption of raw meat products such as pork liver, wild boar and deer m ...

2017

Systems proteomics of liver mitochondria function

Johan Auwerx, Evan Graehl Williams, Pooja Jha, Tiffany Amariuta, Ruedi Aebersold, Sébastien Dubuis

Recent improvements in quantitative proteomics approaches, including Sequential Window Acquisition of all Theoretical Mass Spectra (SWATH-MS), permit reproducible large-scale protein measurements across diverse cohorts. Together with genomics, transcriptom ...

American Association for the Advancement of Science2016

Visualization of hepatic arteries with 3D ultrasound during intra-arterial therapies

Anaïs Laure Marie-Thérèse Badoual, François Michaud, Alexandre Bigot

Liver cancer represents the second most common cause of cancer-related mortality worldwide. The prognosis is poor with an overall mortality of 95%. Moreover, most hepatic tumors are unresectable due to their advanced stage at discovery or poor underlying l ...

Spie-Int Soc Optical Engineering2016

Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in LdIr(-/-) Mice

Freddy Radtke

Non-alcoholic steatohepatitis (NASH) is characterized by liver steatosis and inflammation. Currently, the underlying mechanisms leading to hepatic inflammation are not fully understood and consequently, therapeutic options are poor. Non-alcoholic steatohep ...

Public Library of Science2016

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis

Johan Auwerx, Jiujiu Yu

We report the engineering and characterization of paraoxonase-3 knockout mice (Pon3KO). The mice were generally healthy but exhibited quantitative alterations in bile acid metabolism and a 37% increased body weight compared to the wild-type mice on a high ...

Federation of American Society of Experimental Biology2015

Performance of Serum microRNAs-122,-192 and-21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis

Christian Hammer

Objectives Liver biopsies are the current gold standard in non-alcoholic steatohepatitis (NASH) diagnosis. Their invasive nature, however, still carries an increased risk for patients' health. The development of non-invasive diagnostic tools to differentia ...

Public Library of Science2015

1H MRS to investigate the hepatic profile of GLUT2-/- mice

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

We performed 1H MRS at 14.1T in the liver of GLUT2-/- and wild-type (WT) mice. Improved spectral resolution allowed identifying peaks from the lipid resonances, choline containing compounds, taurine and glycogen in WT mice. Performing the same measurements ...

2014

Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP

Kristina Schoonjans

Background: Liver physiology is sensitive to estrogens, which suggests that the liver might be a target of estrogenic endocrine disrupters (EED). However, the long-term consequences of neonatal exposure to EED on liver physiology have rarely been studied. ...

Informa Healthcare2014

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Hepatotoxicity

Integration of the role of climate in the spatial modeling of waterborne hepatitis E virus

Modeling the present and future distribution of waterborne Hepatitis E virus

Systems proteomics of liver mitochondria function

Visualization of hepatic arteries with 3D ultrasound during intra-arterial therapies

Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in LdIr(-/-) Mice

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis

Performance of Serum microRNAs-122,-192 and-21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis

Targeting Tumor Vasculature with Aptamer-Functionalized Doxorubicin - Polylactide Nanoconjugates for Enhanced Cancer Therapy

1H MRS to investigate the hepatic profile of GLUT2-/- mice

Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP

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Modeling the present and future distribution of waterborne Hepatitis E virus

Integration of the role of climate in the spatial modeling of waterborne hepatitis E virus

Targeting Tumor Vasculature with Aptamer-Functionalized Doxorubicin - Polylactide Nanoconjugates for Enhanced Cancer Therapy

Systems proteomics of liver mitochondria function

Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in LdIr(-/-) Mice

Performance of Serum microRNAs-122,-192 and-21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis

1H MRS to investigate the hepatic profile of GLUT2-/- mice

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis

Visualization of hepatic arteries with 3D ultrasound during intra-arterial therapies

Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP