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Nine 1,3-dichlorobenzene congeners were selected as model compds. to assess the relative rates of proton abstraction from 4- and 5-positions ("ortho" vs. "meta" metalation). Using lithium 2,2,6,6-tetramethylpiperidide as the basic reagent, the chlorine-adj ...
5-Pyrimidyllithium species are fairly stable when the metal is flanked by two electron-withdrawing substituents such as trifluoromethyl and chlorine or bromine. Thus, the corresponding 5-carboxylic acids are produced in high yields from 4,5-dibromo-6-(trif ...
A new one-pot synthesis of sulfoxides is presented. It involves the bora-ene reaction of sulfur dioxide and prop-2-ene-1-boronic esters, giving mixed anhydrides of sulfinic and boric acids. The latter react chemoselectively at the sulfur center with Grigna ...
Efficient routes to 3-(1,2,3-triazol-1-yl)- and 3-(1,2,3-triazol-4-yl)pyrazolo[3,4-d]pyrimidin-4-amines using a one-pot two-step reaction are presented. The two routes give easy access to two different isomers of 1,4-disubstituted triazoles and the target ...
Ni-catalyzed Sonogashira coupling of nonactivated, β-H- containing alkyl halides, including chlorides, is reported. The coupling is tolerant to a wide range of functional groups, including ether, ester, amide, nitrile, keto, heterocycle, acetal, and aryl h ...
Identification of proteins in 3D maps of cells is a main challenge in structural cell biology. For light microscopy (LM) clonable reagents such as green fluorescent protein represented a real revolution and equivalent reagents for transmission electron mic ...
This invention pertains to light emitting materials comprising novel ortho-metalated transition metal complexes [C^N] 2 ML comprising two orthometalated ligands having imidazole moieties and an ancillary ligand of ²-diketonate type. It has been surprisingl ...
A new pincer-type bis(amido)amine (NN2) ligand and its lithium and nickel complexes, including Ni(II) methyl, ethyl, and phenyl complexes, were synthesized. The Ni(II) alkyl complexes react cleanly with alkyl halides including chlorides to form C−C coupled ...
A conceptually novel macrolactonization protocol has been developed. It is a domino process involving a sequence of: (1) protonation of 5-aminooxazole leading to the electrophilic iminium salt; (2) trapping of the iminium species by the neighboring C-termi ...
Alkylation of alpha -isocyanoacetamide with alkyl halide in MeCN at 0 DegC in the presence of cesium hydroxide afforded the mono-alkylated product in good to excellent yield. [on SciFinder (R)] ...