Publications related to Sequence assembly

Middle-down analysis of monoclonal antibodies with electron transfer dissociation Orbitrap FTMS

Yury Tsybin, Luca Fornelli, Daniel Ayoub

The rapid growth of approved biotherapeutics, e.g., monoclonal antibodies or immunoglobulins G (IgGs), demands improved techniques for their quality control. Traditionally, proteolysis-based bottom-up mass spectrometry (MS) has been employed. However, the ...

Amer Chemical Soc2014

Mycobacterium leprae genomes from a British medieval leprosy hospital: towards understanding an ancient epidemic

Stewart Cole, Pushpendra Singh

Background: Leprosy has afflicted humankind throughout history leaving evidence in both early texts and the archaeological record. In Britain, leprosy was widespread throughout the Middle Ages until its gradual and unexplained decline between the 14th and ...

Biomed Central Ltd2014

Advantages of Extended Bottom-Up Proteomics Using Sap9 for Analysis of Monoclonal Antibodies

Yury Tsybin, Luca Fornelli, Kristina Srzentic, Unige Anna Laskay, Daniel Ayoub

Despite the recent advances in structural analysis of monoclonal antibodies with bottom-up, middle-down, and top-down mass spectrometry (MS), further improvements in analysis accuracy, depth, and speed are needed. The remaining challenges include quantitat ...

Amer Chemical Soc2014

Classification of selectively constrained DNA elements using feature vectors and rule-based classifiers

Philipp Bucher, Slavica Dimitrieva Janeva

Scarce work has been done in the analysis of the composition of conserved non-coding elements (CNEs) that are identified by comparisons of two or more genomes and are found to exist in all metazoan genomes. Here we present the analysis of CNEs with a metho ...

Academic Press Inc Elsevier Science2014

Linking microbial population dynamics and nutrient removal during wastewater treatment

Christof Holliger, David Gregory Weissbrodt

A methodology combining molecular fingerprinting, pyrosequencing-based identification of phylotypes with PyroTRF-ID, and multivariate statistics was developed to investigate on the long run, with high resolution and low cost, the dynamics of bacterial popu ...

2013

Genome-wide comparison of medieval and modern Mycobacterium leprae

Stewart Cole, Andrej Benjak, Philippe Busso, Pushpendra Singh

Leprosy was endemic in Europe until the Middle Ages. Using DNA array capture, we have obtained genome sequences of Mycobacterium leprae from skeletons of five medieval leprosy cases from the United Kingdom, Sweden, and Denmark. In one case, the DNA was so ...

Amer Assoc Advancement Science2013

Detecting the translocation of DNA through a nanopore using graphene nanoribbons

Aleksandra Radenovic, Andras Kis, Ke Liu, Daria Krasnozhon, Camille Alice Raillon, Floriano Traversi, Mohamed Malik Benameur, Sergey Khlybov

Solid-state nanopores can act as single-molecule sensors and could potentially be used to rapidly sequence DNA molecules. However, nanopores are typically fabricated in insulating membranes that are as thick as 15 bases, which makes it difficult for the de ...

Nature Publishing Group2013

The genome of Dehalobacter restrictus - high gene redundancy for a restricted metabolism

Christof Holliger, Julien Maillard, Aamani Rupakula Boyanapalli, Hauke Smidt

Organohalide respiration (OHR) is a bacterial anaerobic respiratory metabolism dedicated to use halogenated compounds as terminal electron acceptors. OHR bacteria are strictly anaerobic microorganisms which use reductive dehalogenases (RdhA) as key enzymes ...

2012

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Sequence assembly

Models and Algorithms for Comparative Genomics

Middle-down analysis of monoclonal antibodies with electron transfer dissociation Orbitrap FTMS

Mycobacterium leprae genomes from a British medieval leprosy hospital: towards understanding an ancient epidemic

Advantages of Extended Bottom-Up Proteomics Using Sap9 for Analysis of Monoclonal Antibodies

Classification of selectively constrained DNA elements using feature vectors and rule-based classifiers

Linking microbial population dynamics and nutrient removal during wastewater treatment

Genome-wide comparison of medieval and modern Mycobacterium leprae

Quality- and cost-driven assembly technique selection and geometrical tolerance allocation for mechanical structure assembly

Detecting the translocation of DNA through a nanopore using graphene nanoribbons

The genome of Dehalobacter restrictus - high gene redundancy for a restricted metabolism

Graph Chatbot

Chat with Graph Search

Mycobacterium leprae genomes from a British medieval leprosy hospital: towards understanding an ancient epidemic

Quality- and cost-driven assembly technique selection and geometrical tolerance allocation for mechanical structure assembly

The genome of Dehalobacter restrictus - high gene redundancy for a restricted metabolism

Models and Algorithms for Comparative Genomics

Middle-down analysis of monoclonal antibodies with electron transfer dissociation Orbitrap FTMS

Genome-wide comparison of medieval and modern Mycobacterium leprae

Advantages of Extended Bottom-Up Proteomics Using Sap9 for Analysis of Monoclonal Antibodies

Classification of selectively constrained DNA elements using feature vectors and rule-based classifiers

Linking microbial population dynamics and nutrient removal during wastewater treatment

Detecting the translocation of DNA through a nanopore using graphene nanoribbons