Concept

Neocortex

Related publications (129)

The dynamical response properties of neocortical neurons to temporally modulated noisy inputs in vitro

Cortical neurons are often classified by current-frequency relationship. Such a static description is inadequate to interpret neuronal responses to time-varying stimuli. Theoretical studies suggested that single-cell dynamical response properties are neces ...

Oxford University Press2008

The excitatory neuronal microcircuit of the C2 column in the mouse primary somatosensory cortex

Sandrine Lefort

Rodents are nocturnal animals gathering information about their surroundings by using highly sensitive detectors laid out on their snout. Like humans use their fingertips to apprehend textures, rodents use their whiskers to build a spatial representation o ...

EPFL2008

Recruiting new neurons from the subventricular zone to the rat postnatal cortex: an organotypic slice culture model

The neurogenic subventricular zone (SVZ) of the lateral ventricle is a potential source for neuronal replacement in the postnatal or adult neocortex after injury. Here we present a novel model system to directly explore the cellular mechanisms of this proc ...

2008

Molecular heterogeneity of the ganglionic eminence and its relationship to the birth of neocortical interneurons

Susan Willi Monnerat

Neocortical function and malfunction depends critically on a spectrum of inhibitory interneurons. To gain novel insight in normal brain function and mechanisms leading to diseases, such as epilepsy or schizophrenia, the knowledge about the specific functio ...

EPFL2007

Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex

Henry Markram, Gilad Silberberg, Jean-Vincent Le Bé, Yi Wang

Neocortical pyramidal cells (PCs) project to various cortical and subcortical targets. In layer V, the population of thick tufted PCs (TTCs) projects to subcortical targets such as the tectum, brainstem, and spinal cord. Another population of layer V PCs p ...

Oxford University Press2007

Layer- and column-specific knockout of NMDA receptors in pyramidal neurons of the mouse barrel cortex

Carl Petersen, Rachel Aronoff

Viral vectors injected into the mouse brain offer the possibility for localized genetic modifications in a highly controlled manner. Lentivector injection into mouse neocortex transduces cells within a diameter of approximately 200mum, which closely matche ...

Frontiers Research Foundation2007

Differential spatial representation of taste modalities in the rat gustatory cortex

Carl Petersen, Riccardo Accolla

Discrimination between foods is crucial for the nutrition and survival of animals. Remarkable progress has been made through molecular and genetic manipulations in the understanding of the coding of taste at the receptor level. However, much less is known ...

2007

Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells

Henry Markram, Gilad Silberberg

Reliable activation of inhibitory pathways is essential for maintaining the balance between excitation and inhibition during cortical activity. Little is known, however, about the activation of these pathways at the level of the local neocortical microcirc ...

2007

Expression of FGF-2 in neural progenitor cells enhances their potential for cellular brain repair in the rodent cortex

Didier Trono, Marc-Olivier Sauvain, Michiko Kanemitsu

Strategies to enhance the capacity of grafted stem/progenitors cells to generate multipotential, proliferative and migrating pools of cells in the postnatal brain could be crucial for structural repair after brain damage. We investigated whether the over-e ...

Oxford University Press2007

Abnormal patterns of cortical gyrification in velo-cardio-facial syndrome (deletion 22q11.2): an MRI study

Marie Schaer, François Lazeyras

Velo-cardio-facial syndrome (VCFS), also known as 22q11.2 deletion syndrome, is a common genetic condition associated with increased risk for developing schizophrenia. Given that cortical malformations play an integral role in the pattern of neuroanatomica ...

2006

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