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Neurons generate spikes reliably with millisecond precision if driven by a fluctuating current—is it then possible to predict the spike timing knowing the input? We determined parameters of an adapting threshold model using data recorded in vitro from 24 l ...
The neocortex has a high capacity for plasticity. To understand the full scope of this capacity, it is essential to know how neurons choose particular partners to form synaptic connections. By using multineuron whole-cell recordings and confocal microscopy ...
Activation dynamics of hippocampal subregions during spatial learning and their interplay with neocortical regions is an important dimension in the understanding of hippocampal function. Using the (14C)-2-deoxyglucose autoradiographic method, we have chara ...
The goal of our work aims at implementing progressively an action selection affective model for virtual humans that should be in the end autonomous, adaptive and sociable. Affect, traditionallydistinguished from "cold" cognition, regroups emotions and moti ...
Autism is a wide-spectrum disorder with early childhood onset, affecting general cognitive capabilities and, in particular, complex information processing. Although interesting directions of research start to appear, the precise causes of the disorder and ...
Minimal nonlinear dynamic neuron models of the generic bifurcation type may provide the middle way between the detailed models favored by experimentalists and the simplified threshold and rate model of computational neuroscientists. This thesis investigate ...
Development of technologies in the field of neuroimaging brought an increase interest in the quantification of cortical folding (gyrification), notably for neurogenetic and psychiatric disorders that may result from an early abnormal cortical development. ...
Motor impairment resulting from chronic stroke can have extensive physical, psychological, financial, and social implications despite available neurorehabilitative treatments. Recent studies in animals showed that direct epidural stimulation of the primary ...
The structure of cross-correlations between subthreshold potentials of neocortical neurons was recently examined. Characteristic features included broad widths and significant peak advances. It was suggested that dynamic synapses shape these cross-correlat ...
This work investigates the capacity of Integrate-and-Fire-type (I&F-type) models to quantitatively predict spike trains of real neurons in various laboratory and in vivo-like settings. A step-by-step methodology is developed to build an equivalent effectiv ...