Concept
Thrombolysis
Related publications (15)
Bistable Puncturing Tool for Retinal Vein Cannulation
Yves Bellouard, Simon Nessim Henein, Charles Baur, Lisa Anaïs Jeanne Bonnefoy
An innovative surgical tool prototype dedicated to safe puncturing has been developed for the treatment of retinal vein occlusions (RVOs). The tool is manufactured monolithically by femtolaser printing in fused silica. It consists of a programmable bistabl ...
2020Programmable Multistable Mechanisms for Safe Surgical Puncturing
Simon Nessim Henein, Charles Baur, Andrea Lovera, Ilan Vardi, Mohamed Gamal Abdelrahman Ahmed Zanaty, David Lambelet, Thomas Jean Julien Fussinger, Arno Rogg
We present novel medical devices for safe surgical puncturing, in particular a cannula for the treatment of retinal vein occlusion (RVO). This passive mechanical device has an adjustable stroke and exerts a puncturing force independent of operator applied ...
ASME2019Development of cyclic peptide inhibitors of coagulation factor XII and matrix metalloproteinase 2
Peptides represent a promising molecular class for drug development. They combine several strengths of small molecules (e.g. efficient tissue diffusion, low immunogenicity and access to chemical synthesis) and key properties of biologics such as monoclonal ...
EPFL2018Intra-Arterial Drug and Light Delivery for Photodynamic Therapy Using Visudyne (R): Implication for Atherosclerotic Plaque Treatment
Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Manish Jain
Photodynamic therapy (PDT), which is based on the activation of photosensitizers with light, can be used to reduce plaque burden. We hypothesized that intra-arterial photosensitizer administration and photo-activation will lead to high and rapid accumulati ...
2016Recombinant tissue plasminogen activator induces blood-brain barrier breakdown by a matrix metalloproteinase-9-independent pathway after transient focal cerebral ischemia in mouse
Rafaela Fernandes Da Silva, Jean-Christophe Copin
The role of the inducible matrix metalloproteinase (MMP)-9 in blood-brain barrier (BBB) disruption after ischemic stroke is well accepted. Recombinant tissue plasminogen activator (r-tPA) is the only approved thrombolytic treatment of ischemic stroke but r ...
Wiley-Blackwell2011Construction of a Recombinant Plasminogen Activator with a Novel Fibrin Targeting Motif
Thomas Barker, Cédric Xavier Paulou
[...] Peritoneal adhesions are pathological fibrous structures that connect together organ and membrane at sites where the peritoneum is damaged. Post-operative adhesions forming after abdominal surgery have a very high occurrence and can develop painful a ...
2008Reproducibility of haemodynamical simulations in a subject-specific stented aneurysm model - A report on the Virtual Intracranial Stenting Challenge 2007
Philippe Reymond, Luca Augsburger, Daniel Ruefenacht
This paper presents the results of the Virtual Intracranial Stenting Challenge (VISC) 2007, an international initiative whose aim was to establish the reproducibility of state-of-the-art haemodynamical simulation techniques in subject-specific stented mode ...
2008Induction of plasminogen activator inhibitor I by the PPARalpha ligand, Wy-14,643, is dependent on ERK1/2 signaling pathway
Impairment of the fibrinolytic system, mostly due to elevated plasma levels of plasminogen activator inhibitor 1 (PAI-1), is often associated with metabolic disorders such as diabetes mellitus and insulin-resistance syndrome. Moreover, insulin, as we have ...
2003Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation
Johan Auwerx, Kristina Schoonjans
BACKGROUND: The peroxisome proliferator-activated receptor alpha (PPARalpha) plays an important role in the metabolism of lipoproteins and fatty acids, and seems to protect against the development of atherosclerosis. To evaluate the possible protective rol ...
2002Local release of fibrinolytic agents for adhesion prevention
Tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), and streptokinase were evaluated for their ability to reduce postsurgical adhesion formation in a rat uterine horn devascularization and serosal injury model in a blinded, randomize ...
1995