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Related publications (179)

Development and Characterization of a Microfluidic Chip to Capture Circulating Prostate Cancer Cells

The analysis of circulating tumor cells (CTCs) from the blood of cancer patients promises a better understanding of metastasis formation and tumor phenotypes. CTCs are rare (there is 1 CTC in 1 billion of circulating blood cells) and therefore challenging ...

2011

Capillary Microfluidic Chips for Point-of-Care Testing

Luc Gervais

Research on microfluidic devices for biological analysis has progressed sufficiently to be developed into point-of-care diagnostics products. The goal of this thesis is to improve multiple aspects of capillary-driven microfluidic devices. In particular, th ...

EPFL2011

Optical Trapping in Microfluidic Channels for Functional and Chemical Analysis of Single Cells

Michael Werner

The physiological properties of cells are typically investigated in ensembles yielding averaged data that mask heterogeneities present in any cell population. Single-cell analysis techniques based on microfluidic "lab on a chip" (LOC) devices have recently ...

EPFL2011

Protein-Binding Microarray Analysis of Tumor Suppressor AP2 alpha Target Gene Specificity

Horst Vogel, Luigino Grasso, Jan Kerschgens, Tanja Egener-Kuhn, Nicolas Mermod, Hans-Anton Lehr

Cheap and massively parallel methods to assess the DNA-binding specificity of transcription factors are actively sought, given their prominent regulatory role in cellular processes and diseases. Here we evaluated the use of protein-binding microarrays (PBM ...

Public Library of Science2011

Development of bioreporter assays for the detection of bioavailability of long chain alkanes based on the marine bacterium Alcanivorax borkumensis strain SK2

Jeremy Samuel Arey, Rebecca Rutler

Long-chain alkanes are a major component of crude oil and therefore potentially good indicators of hydrocarbon spills. Here we present a set of new bacterial bioreporters and assays that allow to detect long-chain alkanes. These reporters are based on the ...

2011

Characterization of New Potential Anticancer Drugs Designed To Overcome Glutathione Transferase Mediated Resistance

Paul Joseph Dyson, Wee Han Ang, Jie Zhang

Resistance against anticancer drugs remains a serious obstacle in cancer treatment. Here we used novel strategies to target microsomal glutathione transferase 1 (MGST1) and glutathione transferase pi (GSTP) that are often overexpressed in tumors and confer ...

2011

Resonances arising from hydrodynamic memory in Brownian motion

László Forró, Flavio Maurizio Mor, Giuseppe Foffi, Sylvia Jeney, Maxim Belushkin, Matthias Grimm

Observation of the Brownian motion of a small probe interacting with its environment provides one of the main strategies for characterizing soft matter. Essentially, two counteracting forces govern the motion of the Brownian particle. First, the particle i ...

2011

Single Molecule Detection of Nitric Oxide Enabled by d(AT)15 DNA Adsorbed to Near Infrared Fluorescent Single-Walled Carbon Nanotubes

Ardemis Anoush Boghossian

We report the selective detection of single nitric oxide (NO) mols. using a specific DNA sequence of d(AT)15 oligonucleotides, adsorbed to an array of near-IR fluorescent semiconducting single-walled carbon nanotubes (AT15-SWNT). While SWNT suspended with ...

2011

Continuous and label-free toxicity screening of human hepatocytes on chip reveals frequency-dependant impedance profiles

Philippe Renaud, Robert Meissner, Bilge Eker

We present an electrical impedance based biosensor on a microfluidic cell culture platform that enables label-free and re- al-time investigation of drug toxicity-induced effects on hepatocytes. The temporal evolution of the impedance at different frequenci ...

2011

Development of high content image-based cell viability assays

Julien Mena

Aim and applications: 1. Optimize fluorescence-based cellular assays for getting insights about mechanisms leading to cell death 2. Informative high content assays development with the aim to implement them in order to obtain preliminary toxicity informati ...

2010

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